Osorio PI, Salceda SR

Idioma: Español
Referencias bibliográficas: 27
Paginas: 41-48
Archivo PDF: 289.84 Kb.

RESUMEN

El contenido de glucosa, tanto en las células como en el organismo completo, depende de su ingreso, síntesis y consumo. Este flujo se encuentra regulado por señales que son generadas en respuesta a los cambios del estado energético. A nivel orgánico, la sensación de hambre y saciedad, modulada por el hipotálamo, desemboca en la producción de neuropéptidos que estimulan a órganos como el páncreas, intestino y tejido adiposo, que responden y promueven la producción de hormonas, como la insulina y el glucagon, cuyos receptores generan a nivel celular el aumento o disminución del metabolismo de la glucosa. Esta regulación a nivel celular incluye la activación de factores de transcripción de diferentes enzimas, así como su fosoforilación, lo que lleva a un control de su actividad. La fina regulación energética del organismo es un ejemplo claro de la compleja función de la homeostasis celular.

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