Jiménez-López S, Sánchez JE

Language: Spanish
References: 20
Page: 143-148
PDF size: 525.83 Kb.

ABSTRACT

The translation initiation of mRNAs in eukaryotic is a limiting step in protein synthesis, in which ribosomal subunits are assembled with translation initiation factors and mRNA to form an active complex eIF4F. The translation initiation factor eIF4G is the backbone of this complex, because it is a protein scaffold to which various proteins bind as Cap-binding protein eIF4E, the helicase eIF4A and its activator eIF4B. Likewise, it recruits poly-A binding protein (PABP), to facilitates the circularization and stability of the transcript and, in addition, eIF4G helps to position the mRNA on the ribosome 40 S through its eIF3, interaction necessary to form the initiation active 48 S complex.

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