Jiménez-López S, Sánchez JE

Idioma: Español
Referencias bibliográficas: 20
Paginas: 143-148
Archivo PDF: 525.83 Kb.

RESUMEN

El inicio de la traducción de mRNAs eucariontes, es un paso limitante en la síntesis de proteínas, en el cual, las subunidades ribosomales se ensamblan con factores de inicio de la traducción y un mRNA para formar el complejo activo de la traducción eIF4F. El factor de iniciación eIF4G, es la columna vertebral de este complejo de inicio de la traducción, debido a que es una proteína escalafón a la cual se le unen diversas proteínas como la proteína de unión a Cap eIF4E, la helicasa eIF4A y su activador eIF4B. Así mismo, se le une la proteína de unión a la cola de Poli-A (PABP), lo cual facilita la circularización y estabilidad del transcrito. Más aún, eIF4G, ayuda a posicionar al mRNA en el ribosoma 40S a través de su interacción con eIF3, interacción necesaria para formar el complejo de iniciación 48S activo.

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