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2009, Number 4

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Rev Med Inst Mex Seguro Soc 2009; 47 (4)

Comparison of Olopatadin and Ketotifen in the Treatment of Allergic Conjunctivitis

Varguez-Rodríguez ME, Hernández-López A, Gómez-Dávila RÁ

Language: Spanish
References: 26
Page: 399-404
PDF size: 158.46 Kb.


ABSTRACT

Objective: to compare the efficacy of olopatadine 0.1 % and ketotifen 0.025 % ophthalmic solutions in the treatment of allergic conjunctivitis.
Methods: forty patients with allergic conjunctivitis were included in the study, they were randomized in two groups: G-I (n = 20) olopatadine 0.1 % and G-II (n = 20) ketotifen 0.025 %, both receiving one drop every 12 hours. We evaluated itching, burning, tearing, redness and chemosis previously and 30 minutes, one, two and four week after.
Results: age G-I was 19.7 ± 6.7 years; G-II, 21.05 ± 8.3 years. When evaluating itching, olopatadine had a significant improvement at 30 minutes and after one week (p ‹ 0.05). In the following weeks, the results were similar in both groups. Olopatadine showed significant improvement in burning at 30 minutes, one and two week (p ‹ 0.05). Tearing significantly decreased at 30 minutes with olopatadine (p ‹ 0.05). There was no difference in redness or chemosis improvement in both groups.
Conclusions: in this study, olopatadine 0.1 % was more effective than topical ketotifen 0.025 % in improving itching, tearing and burning in allergic conjunctivitis patients.


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