medigraphic.com
ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC

2002, Number 1

<< Back Next >>

An Med Asoc Med Hosp ABC 2002; 47 (1)

Neurohormonal, cardiovascular and renal mechanisms in the obese patient hypertension

Cano RC, Espinosa FR,Toiber GD

Language: Spanish
References: 31
Page: 29-32
PDF size: 36.73 Kb.


ABSTRACT

Obesity is a world public health problem. In Mexico it’s growing rapidly. As a consequence, its complications, like arterial hypertension and its secondary manifestations are present. In this paper we review the neurohormonal mechanisms of leptin, insulin, dopamine, norepinephrin, angiotensin and nitric oxide, and the cardiovascular and renal functions that promotes arterial hypertension in the obese patient.


REFERENCES

  1. Rosembaum M, Leíble RL, Hirsch J. Obesity. N Eng J Med 1997; 337: 396-407.

  2. Kopelman PG. Obesity as a medical problem. Nature 2000; 404: 635-643.

  3. Huber HB. The importance of obesity in the development of coronary risk factors and disease. Annu Rev Public Health 1986; 7: 493-502.

  4. Weindruch R, Sohal RS. Caloric intake and aging. N Eng J Med 1997; 337: 986-995.

  5. Willet WC, Dietz WH. Guidelines for healthy weight. N Eng J Med 1999; 341: 422-433.

  6. Zhang Y. Positional cloning of the mouse ob gene and its human homologue. Nature 1994; 372: 425-432.

  7. Ravussin E. Metabolic differences and the development of obesity. Metabolism 1995; 9 (suppl 3): 12-14.

  8. Barker DJ. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. Br Med J 1989; 298: 654-657.

  9. Hales CN. Fetal and infant growth and impaired glucose tolerance at age 64. Br Med J 1991; 303: 1019-1022.

  10. Hall JE. Renal and cardiovascular mechanism of hypertension in obesity. Hypertension 1994; 23: 381-394.

  11. De Divitis O. Obesity and cardiac function. Circulation 1981; 64: 477-482.

  12. Ahima RS. Role of leptin in the neuroendocrine response to fasting. Nature 1996; 382: 250-252.

  13. Shek EW, Brands MW. Chronic leptin infusion increased arterial pressure. Hypertension 1998; 31: 409-414.

  14. Masuo K, Mikami H, Ogihara T. Weight gain induced blood pressure elevation. Hypertension 2000; 35: 1135-1140.

  15. Meehan WP, Buchanan TA. Chronic insulin administration elevates blood pressure in rats. Hypertension 1994; 23: 1012-1017.

  16. Heise T, Magnusson K. Insulin resistance and the effect of insulin on blood pressure in essential hypertension. Hypertension 1998; 32: 243-248.

  17. Hussain T, Lokhandwala MF. Renal dopamine receptor function in hypertension. Hypertension 1998; 32: 187-197.

  18. Neil TG, Tomlinson B, Critchley J. Modulation of blood pressure and obesity with the dopamine D2 receptor gene Taq 1 polymorphism. Hypertension 2000; 36: 177-182.

  19. Sowers JR, Nyby M. Dopaminergic control of prolactin and blood pressure. Hypertension 1982; 4: 431-438.

  20. Tuck ML. Obesity, the sympathetic nervous system, and essential hypertension. Hypertension 1992; 19: 67-77.

  21. Hall JE. Hyperinsulinemia: a link between obesity and hypertension? Kidney Int 1993; 43: 1402-1417.

  22. Kassab S, Kato T. Renal denervation attenuates the sodium retention and hypertension associated with obesity. Hypertension 1995; 25: 893-897.

  23. Hunt SC, Cook NR, Oberman A. Angiotensinogen genotype, sodium reduction, weight loss, and prevention of hypertension (TOHP). Hypertension 1998; 32: 393-401.

  24. Christian R, Nosratola V. Enhanced NO inactivation and hypertension induced by a high fat, refined carbohydrate diet. Hypertension 2000; 36: 423-429.

  25. Anca D, Michael D. Oxidative stress in a rat model of obesity induced hypertension. Hypertension 2001; 37: 554-560.

  26. Lausen JB, Rajagopalan S. Role of superoxide in angiotensin II induced but not catecholamine induced hypertension. Circulation 1997; 95: 588-593.

  27. Weisinger JR, Kempson RL. The nephrotic syndrome: A complication of massive obesity. Ann Intern Med 1974; 81: 440-447.

  28. Licata G, Volpe M. Salt regulating hormones in young normotensive obese subjects. Hypertension 1994; 23: 20-24.

  29. Kambham N, Markowitz G. Obesity related glomerulophaty. An emerging epidemic. Kidney Int 2001; 59: 1498-1509.

  30. Wolf G, Hamann A. Leptin stimulates proliferation and TGF-b expression in renal glomerular endothelial cells. Kidney Int 1999; 56: 860-872.

  31. Keane WF. Lipids and the kidney. Kidney Int 1994; 46: 910-920.




2020     |     www.medigraphic.com