2012, Number 2
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Enf Infec Microbiol 2012; 32 (2)
Moderate acne, utility of combined treatment with antibiotics
Vallejos MC, Enríquez GMÁ, López VMR, Valdéz GJA, Ramírez VB, Zamora OR
Language: Spanish
References: 21
Page: 55-60
PDF size: 291.81 Kb.
ABSTRACT
Acne vulgaris is the most common skin disease worldwide. Its etiology is multifactorial and the clinical manifestations vary from mild to serious skin disease.
Material and methods. A retrospective study was conducted reviewing clinical records of patients seen in outpatient settings. Topical treatments were evaluated in the mild acne group, and systemic treatments in the moderate acne group.
Results. There were studied 280 patients: 132 men (47.1%), 148 women (52.9%), 146 patients (52.1%) had moderate acne and 134 mild acne. In cases of mild acne, 53/67 patients (79.1%) had a better response to combined topical treatment and 29/67 (43.3%) with topical retinoid. In the group of moderate acne 68/73 patients (93.2%) showed improvement combined with systemic therapy and 44/73 (68.5%) responded to retinoid.
Conclusions. Combination therapy shows better results than monotherapy in patients who progress from the non-inflammatory until inflammatory acne. This can be explained by the sensitivity of P. acnes to antibiotics used (tetracycline).
REFERENCES
Kaminer, MS, Gilchrest, BA. “The many faces of acne”. J Am Acad Dermatol 1995; 32:S6.
Collier, CN, Harper, JC, Cantrell, WC, et al. « The prevalence of acne in adults 20 years and older”. J Am Acad Dermatol 2008; 58:56.
Goulden, V, Clark, SM, Cunliffe, WJ. “Post-adolescent acne: a review of clinical features”. Br J Dermatol 1997; 136:66.
Nielsen, ML, Raahave, D, Stage, JG, Justesen, T. “Anaerobic and aerobic skin bacteria before and after skindisinfection with chlorhexidine: an experimental study in volunteers”. J Clin Pathol 1975; 28:793.
Puhvel, SM, Sakamato, M. “The chemoattractant properties of comedonal components”. J Invest Dermatol 1978; 71:324.
Stoll, S, Shalita, AR, Webster, GF, et al. “The effect of the menstrual cycle on acne”. J Am Acad Dermatol 2001; 45:957.
Fern A Wirth, Robert P Dellavalle, Moise L Levy, Abena O Ofori. “Approach to acne vulgaris”. Up to Date 2009, 17.1 v 1.2.
Voorhees JJ, Wilkins JW y Hayes E. XXY “Chromosomal complement and Nodulocystic acne”. Annals of Internal Medicine. 1972, 73(2): 271-275.
Rasmussen, JE, Smith, SB. “Patient concepts and misconceptions about acne”. Arch Dermatol 1983; 119:570.
Yosipovitch, G, Tang, M, Dawn, AG, et al. “Study of psychological stress, sebum production and acne vulgaris in adolescents”. Acta Derm Venereol 2007; 87:135.
White GM. “Recent findings in the epidemiologic evidence, classification, and subtypes of acne vulgaris”. J Am Acad Dermatol 1998; 39 (Suppl):S34-7.
Simpson NB & Cunliffe WJ. Disorders of the Sebaceous Glands. Rook’s Textbook of Dermatology. 2004; 7: 43.1-43.75.
Disorders of Sebaceous and Apocrine Glands. Fitzpatrick’s Color Atlas & Synopsis of Clinical Dermatology, Fifth Ed, 2005.
Suei, Y, Taguchi, A, Tanimoto, K, et al. “Case report. Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome”. Dentomaxillofac Radiol 1996; 25:287.
Goldstein, BG, Goldstein, AO. Diagnostic procedures in Practical Dermatology. 2nd ed, Mosby-year Book, Inc, 1997; p. 26.
Leyden, JJ. “Therapy for acne vulgaris”. N Engl J Med 1997; 336:1156.
Lookingbill, DP, Chalker, DK, Lindholm, JS, et al. “Treatment of acne with a combination clindamycin/benzoyl peroxide gel and vehicle gel: Combined results of two double-blind investigations”. J Am Acad Dermatol 1997; 37:590.
Cooper, AJ. “Systematic review of Propionibacterium acnes resistance to systemic antibiotics”. Med J Aust 1998; 169:259.
Ortonne, JP. “Oral isotretinoin treatment policy. Do we all agree?” Dermatol 1997; 195:34.
“Blue Light (Clearlight) for Acne Vulgaris”. Med Lett Drugs Ther 2003; 45:50.
Webster, GF. “Laser treatment of acne”. Lancet 2003; 362:1342.
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