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ISSN 1561-3011 (Electronic)

2011, Number 4

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Rev Cubana Invest Bioméd 2011; 30 (4)

Genetic, immunologic and environmental factors associated with autoimmunity

Torres OS, Martínez CZ

Language: Spanish
References: 28
Page: 501-510
PDF size: 167.25 Kb.


ABSTRACT

The autoimmunity is characterized by a loss of immunologic tolerance producing the destruction of cells and own tissues. The major complex system of histocompatibility has a close association with the autoimmune diseases although determined genes codifying for cytokines and co-stimulators molecules increase the genetic susceptibility. Concordance studies among monozygotic twins demonstrate the role of environmental factors in appearance of autoimmune diseases. Despite the scientific advances achieved in this research field, the underlying mechanisms of these affections are unknown. The objective of present paper is to expose in a summarized way the role of the genetic, immunologic and environmental factors in autoimmunity.


REFERENCES

  1. Adams DD, Knight JG, Ebringer A. Autoimmune diseases: Solution of the environmental, immunological and genetic components with principles for immunotherapy and transplantation. Autoimmunity Rev. 2010;9:525-30.

  2. Ermann J, Fathman CG. Autoimmune diseases: genes, bugs and failed regulation. Nature Immunology. 2001;2:759-62.

  3. Abbas K, Litcham H, Pillai S. Inmunología celular y molecular. Sexta edicion. Falta la ciudad Elsevier Saunders; 2010.

  4. Browning M, McMichael A, ed. HLA and MHC: genes, molecules and function. Oxford: BIOS Scientific Publ. Ltd.; 1996.

  5. Arnold B. Levels of peripheral T cell tolerance. Transplant Immunol. 2002;10:109-14.

  6. Undlien DE, Lie BA, Thorsby E. HLA complex genes in type 1 diabetes and other autoimmune diseases. Which genes are involved? Trends Genet. 2001;17:93-100.

  7. Thorsby E, Lie BA. HLA associated genetic predisposition to autoimmune diseases: Genes involved and possible mechanisms. Transplant Immunol. 2005;14:175-82.

  8. Thorsby E, Lie BA. Several genes in the extended human MHC contribute to predisposition to autoimmune diseases. Curr Opin in Immun. 2005;17:526-31.

  9. Cassinotti A, Birindelli S, Clerici M, Trabattoni D, Lazzaroni M, Ardizzone S, et al. HLA and Autoimmune Digestive Disease: A Clinically Oriented Review for Gastroenterologists. Am J Gastroenterol. 2009;104:195-217.

  10. Caillat-Zucman S. Molecular mechanisms of HLA association with autoimmune diseases. Tissue Antigens. 2008;73:1-8.

  11. Shiina T, Inoko H, Kulski JK. An update of the HLA genomic region, locusinformation and disease associations. Tissue Antigens. 2004;64:631-49.

  12. Waldner H. The role of innate immune responses in autoimmune disease development. Autoimmunity Rev. 2009;8:400-04.

  13. Lie BA, Akselsen HE, Bowlus CL, Gruen JR, Thorsby E, Undlien DE. Polymorphisms in the gene encoding thymus-specific serine protease in the extended HLA complex: a potential candidate gene for autoimmune and HLA-associated diseases. Genes Immun. 2002;3:306-12.

  14. Björses P, Aaltonen J, Horelli-Kuitunen N, Yaspo M, Peltonen L. Gene defect behind APECED: a new clue to autoimmunity. Hum Mol Gen. 1998;7:1547-53.

  15. Fierabracci A. Recent insights into the role and molecular mechanisms of the autoimmune regulator (AIRE) gene in autoimmunity. Autoimmun Rev. 2011;10:137-43.

  16. Rioux JD, Abbas AK. Paths to understanding the genetic basis of autoimmune disease. Nature. 2005;435:584-89.

  17. Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature. 2003;423:506-11.

  18. Langier S, Sade K, Shmuel K. Regulatory T cells: The suppressor arm of the immune system. Autoimmun Rev. 2010;10:112-15.

  19. Fontenot JD, Gavin MA, Rudensky AY. FOXP3 programs the development and function of CD4+CD25+ regulatory T cells. Nature Immunol. 2003;4:330-36.

  20. Bennett CL. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nature Genet. 2001;27:20-21.

  21. Fisher GH. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell. 1995;81:935-46.

  22. Atkinson JP. Complement deficiency: predisposing factor to autoimmune syndromes. Clin Exp Rheumatol. 1989;7:95-101.

  23. Zanelli E, Breedveld FC, de Vries RRP. HLA association with autoimmune disease: a failure to protect? Rheumatology. 2000;39:1060-66.

  24. Proal AD, Albert PJ, Marshall T. Autoimmune disease in the era of the metagenome. Autoimmunity Rev. 2009;8:677-81.

  25. Doria A, Sarzi-Puttini P, Shoenfeld Y. Infections, rheumatism and autoimmunity: the con.icting relationship between humans and their environment. Autoimmun Rev. 2008;3:243-46.

  26. Ryan KR, Patel SD, Stephens LA, Anderton SM. Death, adaptation and regulation: the three pillars of immune tolerance restrict the risk of autoimmune disease caused by molecular mimicry. J Autoimmun. 2007;29:262-71.

  27. Bach JF. Infections and autoimmune diseases. J Autoimmun. 2005;25:74-80.

  28. Bach JF. The effect of infections on susceptibility to autoimmune and allergic disease. N Engl J Med. 2002;347:911-20.




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