medigraphic.com
ISSN 1561-3011 (Digital)

2011, Número 4

<< Anterior Siguiente >>

Rev Cubana Invest Bioméd 2011; 30 (4)


Plantas y hongos comestibles en la modulación del sistema inmune

Llauradó MG, Morris QHJ, Marcos AJ, Castán CL, Bermúdez SRC

Idioma: Español
Referencias bibliográficas: 77
Paginas: 511-527
Archivo PDF: 201.92 Kb.


RESUMEN

Introducción: Se presenta una revisión que considera resultados de investigaciones que han centrado su atención en la búsqueda de compuestos obtenidos de plantas medicinales y hongos comestibles, capaces de estimular la respuesta inmunitaria.
Objetivos: Recopilar y actualizar la información científica publicada acerca de las plantas medicinales y hongos comestibles activos sobre el sistema inmune.
Métodos: Se realizó una búsqueda bibliográfica de artículos científicos relacionados con la temática, en las bases de datos disponibles (PubMed, EBSCO, SciELO, LILACS, CUMED, MEDNAT) así como varios libros y sitios web.
Resultados: En los estudios realizados se refiere como las principales plantas con actividad inmunomoduladora: Allium sativum (Liliaceae), Aloe vera (Aloaceae), Uncaria tomentosa (Rubiaceae), Morinda citrifolia (Rubiaceae), Echinacea purpurea (Asteraceae) y Mangifera indica (Anacardiaceae). Diversos hongos comestibles activos sobre el sistema inmune han sido examinados: Ganoderma lucidum (Ganodermataceae), Grifola frondosa (Polyporaceae), Lentinus edodes (Agaricaceae), Pleurotus spp. (Pleurotaceae) y Schizophylum commune (Schizophyllaceae), entre otros. Asimismo se destacan las posibilidades que estas fuentes naturales podrían ofrecer en la manipulación de la respuesta inmune, al aumentar la calidad de vida de pacientes con inmunodeficiencias y cáncer.
Conclusiones: El estudio de productos naturales derivados de plantas y hongos comestibles-medicinales ofrece amplias perspectivas para el desarrollo de nuevos agentes inmunomoduladores, eficaces y seguros. Se debe continuar trabajando en la identificación de los principios activos y en la dilucidación del mecanismo mediante el que actúan.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Dahanukar SA, Kulkarni RA, Rege NN. Pharmacology of medicinal plants and natural products. Indian J Pharmacol. 2000;32:81-118.

  2. Tan BKH, Vanitha J. Immunomodulatory and antimicrobial effects of some traditional chinese medicinal herbs: A Review. Current Med Chem. 2004;11:1423-30.

  3. Chin YW, Balunas MJ, Chai HB, Kinghorn AD. Drug discovery from natural sources. AAPS J. 2006;8(2):239-53.

  4. Roggo S. Natural products in drug discovery. Chimia. 2007;61(6):312.

  5. Abbas A, Litchtman A, Pober J. Inmunología Celular y Molecular. (4th ed.) Madrid: Mc Graw Hill; 2002.

  6. Mocellin S. Cancer vaccines: the challenge of developing an ideal tumour killing system. Frontiers in Biosc. 2005;10:2285-2305.

  7. de Cos MA, Merino J. Fármacos inmunosupresores e inmunoestimuladores. En: J. Flórez (Ed.) Farmacología Humana. 3rd. ed. Barcelona: Masson S. A.; 1998. p. 389-406.

  8. Hirotsu T, Toshihiro M, Makoto I, Keisuke T. Adoptive immunotherapy for malignant brain tumours using human peripheral blood mononuclear cells activated by the streptococcal preparation OK-432. Neur Med Chirurg. 2001;41(8):387-92.

  9. Cutler RR. The immune system and some natural agents that may help it fight disease. British J Clin Phytomed. 2003;2:6.

  10. Wasser SP. Medicinal mushrooms Science: History, current status, future trends and unsolved problems. Inter J Med Mushrooms. 2010;12(1):1-16.

  11. Pérez JE, Isaza G, Bueno JG, Arango MC. Efecto de los extractos de Phenax rugosus, Tabebuia chrysantha, Althernantera williamsii y Solanum dolichosepalum sobre el leucograma y la producción de anticuerpos en ratas. Rev Med Risaralda. 2004;10(2):13-21.

  12. Kayser O, Masihi KN, Kiderlen AF. Natural products and synthetic compounds as immunomodulators. Exp Rev Anti-infective Therap. 2003;1(2):319-35.

  13. Wasser SP, Didukh M, Nevo E. Antitumor and immunomodulatory activities of medicinal mushroom polysaccharide and polysaccharide-protein complexes in animals and humans (Review). Mycol Balcan. 2005;2:221-50.

  14. Jones PJ. Clinical nutrition: 7 Functional foodsmore than just nutrition. Can Med Association J. 2002;166(12):1555.

  15. Kuriyama S, Hozawa A, Ohmori K, Shimazu T, Matsui T, Ehihara S, et al. Green tea consumption and cognitive function: a cross-sectional study from the Tsurugaya Project. Am J Clin Nutr. 2006;83:355-61.

  16. Nöthlings U, Wilkens LR, Murphy SP, Hankin JH. Vegetable Intake and Pancreatic Cancer Risk: The Multiethnic Cohort Study. Am J Epidemiol. 2007;165 (2):138-47.

  17. Swinbanks D; O´Brien J. Japan explores the boundary between food and medicine. Nature. 1993;364:180.

  18. Arai S, Morinaga Y, Yoshikawa T, Ichiishi E. Recent trends in functional food science and the industry in Japan. Review. Biosc Biotechnol Biochem. 2002;66(10):2017-29.

  19. Chang S, Buswell J. Mushroom nutriceuticals. World J Microbiol and Biotechnol. 1996;12:473-76.

  20. Zeisel S. Regulation of !nutraceuticals". Science. 1999;285:1853-55.

  21. Smiderle FR, Olsen LM, Carbonero ER, Baggio CH, Freitas CS, Marcon R, et al. Anti-inflammatory and analgesic properties in a rodent model of a (1-3),(1-6)- linked beta-glucan isolated from Pleurotus pulmonarius. Eur J Pharmacol. 2008;597:86-91.

  22. Dietary Supplements Health and Education Act. Public Law 103-417. 25 October 1994. Codified at 42 USC 287C-11.

  23. Wasser S, Didukh M, Nevo E. Dietary supplements from culinary-medicinal mushrooms: a variety of regulations and safety concerns for the 21st century. Inter J Med Mushrooms. 2004;6:231-48.

  24. Sharapin N, Pinzón RS. Fundamentos de Tecnología de productos fitoterapéuticos. Santa Fé de Bogotá. Convenio Andrés Bello. Programa Iberoamericano de Ciencia y Tecnología; 2000.

  25. U.S. Pharmacopeia Convention. USP 30-NF 25. National Formulary 25. 2007. The Official Compendia Standards; 2007.

  26. Chang ST;Buswell JA. Medicinal mushrooms a prominent source of nutriceuticals for the 21 st century. Curr Top Nutraceut Res. 2003;1:257-80.

  27. Grindlay D, Reynolds T. The Aloe vera phenomenon: a review of the property and modern uses of the leaf parenchyma gel. J Ethnopharmacol. 1986;16(2-3):117-51.

  28. Jae KL, Myung KL, Yeo PY, Young SK. Acemannan purified from Aloe vera induces phenotypic and functional maturation of immature dendritic cells. Int Immunopharmacol. 2001;1(7):1275-84.

  29. Pugh N, Ross SA, El Sohly MA, Pasco DS. Characterization of aloeride, a new highmolecular- weight polysaccharide from Aloe vera with potent immunostimulatory activity J Agric Food Chem. 2001;49:1030-34.

  30. Chittezhath M, Kuttan G. Radioprotective activity of naturally occurring organosulfur compounds. Tumori. 2006 92:163-169.

  31. Spelman K, Burns J, Nichols D. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern Med Reviews. 2006;11(2):128-50.

  32. Salman H, Bergman M, Bessler H, Punsky I, Djaldetti M. Effect of a garlic derivative (alliin) on peripheral blood cell immune responses. Int J Immunopharmacol. 1999;21(9):589-97.

  33. Bhattacharyya M, Girish GV, Karmohapatra SK, Samad SA. Systemic production of IFN-alpha by garlic (Allium sativum) in humans. J Interferon Cytokine. 2007;27(5):377-82.

  34. Sheng Y, Akesson C, Holmgren K, Bryngelsson C. An active ingredient of Cat's Claw water extracts: identification and efficacy of quinic acid. J Ethnopharmacol. 2005;96(3):577-84.

  35. Bacher N, Tiefenthaler M, Sturm S, Stuppner H. Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells. British J Haematol. 2006;132(5):615-22.

  36. Sheng Y, Bryngelsson, Pero RW. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. J Ethnopharmacol. 2000;69(2):115-26.

  37. Lamm S, Sheng Y, Pero RW. Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100*. Phytomedicine. 2001;8(4):267-74.

  38. Akesson C, Lindgren H, Pero RW, Leanderson T. An extract of Uncaria tomentosa inhibiting cell division and NF-kappa B activity without inducing cell death. Int Immunopharmacol. 2003;3(13-14):1889-1900.

  39. Whistler W. Tongan herbal medicine. Honolulu, Hawaii: Isle Botanica; 1992.

  40. Duke JA. Handbook of phytochemicals. Boca Raton, FL: CRC Publishing;1992.

  41. Hirazumi A, Furusawa E. An immunomodulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia (Noni) with antitumour activity. Phytotherap Res. 1999;13:380-87.

  42. Furusawa E, Hirazumi A, Story S. Antitumour potential of a polysaccharide-rich substance from the fruit juice of Morinda citrifolia (Noni) on sarcoma 180 ascites tumour in mice. Phytotherap Res. 2003;17(10):1158-64.

  43. Palu AK, Hirazumi AK, West BJ, Deng S. The effects of Morinda citrifolia L. (Noni) on the immune system: its molecular mechanisms of action. J Ethnopharmacol. 2008;115(3):502-06.

  44. Kligler B. Echinacea. American Family Physician. 2003;67(1):77-80.

  45. Perry NB, Burgess EJ, Glennie VL. Echinacea standardization: analytical methods for phenolic compounds and typical levels in medicinal species. J Agric Food Chem. 2001;49 (4):1702-06.

  46. Mishima S, Saito K, Maruyama H. Antioxidant and immuno-enhancing effects of Echinacea purpurea. Biological and Pharmaceutical Bulletin. 2004;27(7):1004-09.

  47. Jurkstiene V, Kondrotas AJ, Kevelaitis E. Compensatory reactions of immune system and action of Purple Coneflower (Echinacea purpurea (L.) Moench) preparations. Medicina. 2004;40(7):657-62.

  48. Freier DO, Wright K, Klein K. Enhancement of the humoral immune response by Echinacea purpurea in female Swiss mice. Immunopharmacol Immunotoxicol. 2003;25(4):551-60.

  49. Hwang SA, Dasgupta A, Actor JK. Cytokine production by non-adherent mouse splenocyte cultures to Echinacea extracts. Clin Chim Acta. 2004;343(1-2):161-66.

  50. Guevara M, González S, Álvarez A, Riaño A. Uso etnomédico de la corteza de Mangifera indica L. en Cuba. Rev Cubana Plant Med. 2004;9(1): Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S102847962004000100013&lng=es&nrm=iso

  51. Núñez AJ, Vélez HT, Aguero J, González J. Isolation and quantitative analysis of phenolic constituents, free sugars, and polyols from mango (Mangifera indica L.) stem bark aqueous decoction used in Cuba as nutritional supplement. J Agric Food Chem. 2002;50:762.

  52. Wasser SP, Weis AL. Therapeutic effects of substances occurring in higher basidiomycetes mushrooms: a modern perspective. Crit Rev Immunol. 1999;19(1):6596.

  53. Costa R, Cunha V, Carvalho R. The immunomodulator role of β −D-glucans as co-adjuvant for cancer therapy. Rev Bras Nutr Clin. 2006;21(2):163-66.

  54. Lull C, Wichers H, Savelkoul H. Antiinflamatory and Immunomodulating properties of fungal metabolites. Mediators Inflammation. 2005;2:63-80.

  55. Camelini CM, Maraschin M, Matos de Mendonça M, Zucco C. Structural characterization of ß-glucans of Agaricus brasiliensis in different stages of fruiting body maturity and their use in nutraceutical products. Biotechnol Letters. 2005;27:129599.

  56. Petrova R, Wasser SP, Mahajna JA, Denchev CM. Potential role of medicinal mushrooms in breast cancer treatment: current knowledge and future perspectives. Inter J Med Mushrooms. 2005;7:141-55.

  57. Wu D, Pae M, Ren Z, Guo Z. Dietary supplementation with white button mushroom enhances natural killer cell activity in C57BL/mice. J Nutr. 2007;137:1472-77.

  58. Biziulevièius GA. Mushroom decoctions, a waste product of food processing, may be a potentially valuable source of immunostimulatory and anticancer substances. Med Hypotheses. 2007;69:693-94.

  59. Kawaguchi T. Cancer metastasis: characterization and identification of the behavior of metastatic tumor cells and the cell adhesion molecules, including carbohydrates. Curr Drug Targets Cardiovasc Haematol Disord. 2005;5:39-64.

  60. Wasonga CG, Okoth SA, Mukuria JC, Omwandho CO. Mushroom polysaccharide extracts delay progression of carcinogenesis in mice. J Exp Ther Oncol. 2008;7:147-52.

  61. Cui J, Chisti Y. Polysaccharopepptides of Coriolus vesicolor: Physiological activity, uses, and production. Biotechnol Advances. 2003;21:109-22.

  62. Chihara G. Recent progress in immunopharmacology and therapeutic effects of polysaccharides. Developments in Biological Standardization. 1992;77:191-97.

  63. Werner GH, Jolles P. Immunostimulating agents: what next? Euro J Biochem. 1996;242:1-19.

  64. Gao YH, Zhou SF. Chemopreventive and tumoricidal properties of Ling Zhi mushroom Ganoderma lucidum (W.Curt.:Fr) Lloyd Aphyllophoromycetideae). Part I. Preclinical and clinical studies (review). Inter J Med Mushrooms. 2004;6(2):95-106.

  65. Cai X, Pi Y, Zhou X, Tian L, Oiao S, Lin J. Hepatoma cell growth inhibition by inducing apoptosis with polysaccharide isolated form Turkey tail medicinal mushrooms, Trametes versicolor (L:Fr) Lloyd (Aphyllophoromycetideae). Inter J Med Mushrooms. 2010;12(3):257-63.

  66. Ishibashi K, Miura N, Adachi Y, Ohno N. Relationship between solubility of grifolan, a fungal 1,3 B- D- glucan, and production of tumor necrosis factor by macrophages in vitro. Biosc Biotechnol Biochem. 2001;65(9):1993-2000.

  67. Dantas MC, Rezende L, Robert J, Oliveira S, Esteves RM, Pinto SL, et al. Aqueous Extract of Culinary-Medicinal Royal Sun Mushroom, Agaricus brasiliensis S. Wasser et al. (Agaricomycetideae) Effects on Immunodepression in Mice. Inter J Med Mushrooms. 2010;12(3):227-34.

  68. Takaku T, Kimura Y, Okuda H. Isolation of an antitumor compound from Agaricus blazei Murrill and its mechanism of action. J Nutr. 2001;5:1409-13.

  69. Tsuchida H, Mizuno M, Taniguchi Y, Ito H. Glucomannam separated from Agaricus blazei mushroom culture and antitunor agent containning as active ingredient. JP Patent No. 11-080206, publ. 26.03. 2001. Japanese Patent and Trademark Office.

  70. Harada T, Miura N, Adachi Y, Nakajima M. Effect of SSG, 1,3-β-glucan from Sparassis crispa on hematopoetic response in cyclophosphamide induce leukopenic mice. Biol Pharm Bull. 2002;25(7):931-39.

  71. Bermúdez RC, Morris HJ, Donoso C, Martinez CE, Ramos EI. Influencia de la luz en la calidad proteica de Pleurotus ostreatus, var. florida. Rev Cub Invest Biomed. 2003;22(4):226-31.

  72. Sánchez A, Royse B. La biología y el cultivo de Pleurotus spp. Ciudad México: Editorial Limusa S.A.; 2001.

  73. Morris HJ, Marcos J, Llauradó G, Fontaine R, Tamayo V, García N, et al. Immunomodulating effects of the hot water extract from Pleurotus ostreatus mycelium on cyclofosfamide treated mice. Micol Apl Int. 2003;15(1):7-13.

  74. Morris HJ, Lebeque Y, Fontaine R, Bermúdez RC, Llauradó G, Marcos J. A note on the in vitro macrophagestimulating activity of water-soluble extracts from mycelium of Pleurotus spp. Food Agric Immunol. 2007;18(1):31-37.

  75. Llauradó G, Morris HJ, Lebeque Y, Fontaine R, Bermúdez RC, Marcos J, et al. Acerca de la funcionalidad de setas comestibles Pleurotus spp.: propiedades bioestimulantes de un extracto acuoso. Rev Cub Quím. 2005;XVII:102-07.

  76. Owuor ED, Kong ANT. Antioxidants and oxidants regulated signal transduction pathways. Biochem Pharmacol. 2002;64:765-70.

  77. Gohil K. Genomic responses to herbal extracts: lessons from the in vitro and in vivo studies with an extract of Ginkgo biloba. Biochem Pharmacol. 2002;64:913-17.




2020     |     www.medigraphic.com