2012, Number 2
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salud publica mex 2012; 54 (2)
Iron, zinc, copper and magnesium nutritional status in Mexican children aged 1 to 11 years
Morales-Ruán MC, Villalpando S, García-Guerra A, Shamah-Levy T, Robledo-Pérez R, Ávila-Arcos MA, Rivera JA
Language: English
References: 40
Page: 125-134
PDF size: 119.20 Kb.
ABSTRACT
Objective. To describe the micronutrient nutritional status of a national sample of 1-11 year old Mexican children surveyed in 2006 in National Health and Nutrition Survey (ENSANUT 2006) and their association with dietary and sociodemographic factors.
Materials and methods. Serum samples were used (n=5 060) to measure the concentrations of ferritin, transferrin receptor, zinc, copper and magnesium.
Results. Prevalence of deficiencies in 1-4 and 5-11y old children were for iron (using low ferritin) 26.0 and 13.0%; zinc, 28.1 and 25.8%, respectively; and copper, ≈30% in both age groups. Magnesium low serum concentrations (MLSC), were found in 12.0% and 28.4% of the children, respectively. Being beneficiary of Liconsa (OR=0.32; C.I.95%, 0.17-0.61) or belonging to higher socioeconomic status (OR=0.63; C.I.95%, 0.41-0.97) were protective against iron deficiency. Increasing age (OR=0.59; C.I.95%, 1.19–1.32) and living in the Central Region (OR=0.59; C.I.95%, 0.36-0.97) were protective against MLSC.
Conclusions. Deficiencies of iron and zinc are serious public health problems in Mexican children.
REFERENCES
Investing in the future. A united call to action on vitamin and mineral deficiencies. Global report 2009. Ottawa, Canada: Micronutrient Initiative, 2009.
Black RE, Allen L H, Bhutta Zq A, Caulfield LE, de Onis M, Ezzati M, et al. Maternal and child undernutrition: global and regional exposures and health consequences. Lancet 2008; 371(9608):243-260.
Allen L, Benoist B, Dary O, Hurrel R. Guidelines on food fortification with micronutrients. Switzerland: World Health Organization, Food and Agricultural Organization of the United Nations, 2006.
4 Stoltzfus RJ. Iron deficiency: global prevalence and consequences. Food Nutr Bull 2003;24:S99-103.
Scholl TO, Reilly T. Anemia, iron and pregnancy outcome. J Nutr 2000;130:443S-447S.
Brown KH, Peerson JM, Baker SJ, Hess SY. Preventive zinc supplementation among infants, preschoolers, and older prepubertal children. Food Nutr Bull 2009; 30:S12-40.
Hess SY, Lönnerdal B, Hotz C, Rivera JA, Brown K. Recent advances in knowledge of zinc nutrition and human health. Food Nutr Bull 2009; 30:S5-11.
Swaminathan R. Magnesium Metabolism and its disorders. Clin Biochem Rev 2003;24: 47-66.
Arnaud JM. Update on the assessment of magnesium status. B J Nutr 2008;99 Suppl 3:S24-36.
Huerta GM, Roemmich NJ, Kington LM, Bovbjerg EV, Weltman LA, Holmes FV, et al. Magnesium deficiency Is associated with insulin resistance in obese children. Diabetes Care 2005;28:1175-1181.
Fraga C. Relevance, essentiality and toxicity of trace elements in human health. Mol Aspects Med 2005;26:235-244.
Desai V, Kaler SG. Role of copper in human neurological disorders. Am J Clin Nutr 2008;88:855S-8S.
Cater MA, Mercer JFB. Copper in mammals: mechanisms of homeostasis and pathophysiology. Molecular Biology of Metal Homeostasis and Detoxification. In: Tamás MJ, Martinoia E (ed). Topics in Current Genetics. Heidelberg, Germany: Springer-Verlag Heiderlberg, 2005: 101-129.
Villalpando S, García-Guerra A, Ramírez-Silva CI, Mejía-Rodríguez F, Matute G, Shamah-Levy T, et al. Iron, zinc and iodide status in Mexican children under 12 years and women 12-49 years of age. A probabilistic national survey. Salud Publica Mex 2003;45 suppl 4:520-529.
Palma O, Shamah-Levy T, Franco A, Olaiz-Fernández G, Méndez I. Metodología. In: Encuesta Nacional de Salud y Nutrición (ENSANUT-2006). Cuernavaca, México: Instituto Nacional de Salud Pública, 2006:19-33.
Resano E, Méndez I, Shamah T, Rivera J, Sepúlveda J. Methods of the National Nutrition Survey 1999. Salud Publica Mex 2003:45 suppl 4:558-564.
Rodríguez-Ramírez S, Mundo-Rosas V, Jiménez-Aguilar A, Shamah- Levy T. Methodology for the analysis of dietary data from the Mexican National Health and Nutrition Survey 2006. Salud Publica Mex 2009;51 suppl 4:523-529.
World Health Organization. Iron deficiency anaemia: assessment, prevention, and control. A guide for programme managers. Geneva: WHO, 2001. WHO/NHD/01.3.
Beguin Y. Soluble transferrin receptor for the evaluation of erythropoiesis and iron status. Clin Chim Acta 2003;329:9-22.
International Zinc Nutrition Consultative Group. Assessment of the risk of zinc deficiency in populations and options for its control. Technical Document #1. Food Nutr Bull 2004;25:S94-S203.
Ghasemi A, Syedmoradi L, Zahediasl S, Azizi F. Pediatric reference values for serum magnesium levels in Iranian subjects. Scand J Clin Lab Invest 2010;70:415-420.
Cordano A. Clinical manifestations of nutritional copper deficiency in infants and children. Am J Clin Nutr 1998;67:S1012-S1016.
Organización Panamericana de la Salud. Principios de orientación para la alimentación complementaria del niño amamantado. Unidad de nutrición, salud de la familia y comunidad. Washington DC: OPS, 2003.
Neufeld LM, Ramakrishnan U. Specific Strategies to Address Micronutrient Deficiencies in the Young Child: Targeted Fortification. In: Pettifor JM, Zlotkin S eds. Micronutrient Deficiencies during the Weaning Period and the First Years of Life. Nestlé Nutrition Workshop Series, Pediatric Program. Vevey: Nestec Ltd and Basel: S Karger 2004;54:83-103.
Lee EJ, Oh EJ, Park YJ, Lee HK, Kim BK. Soluble transferrin receptor (sTfR), Ferritin, and sTfR/log ferritin index in anemic patients with nonhematologic malignancy and chronic Inflammation. Clin Chem 2002;48:1118-1121.
Skikne BS, Flowers CH, Cook JD. Serum transferrin receptor: a quantitative measure of tissue iron deficiency. Blood 1990;75:1870-1876.
Gibson RS. Assessment of Iron Status. Gibson RS, ed. Principles of Nutritional Assessment. New York - Oxford: Oxford University Press 2005:443-476.
Villalpando S, Shamah T, Rivera JA, Lara Y, Monterrubio E. Fortifying milk with ferrous gluconate and zinc oxide in a public nutrition program reduced the prevalence of anemia in toddlers. J Nutr 2006;136:2633-2637.
Rivera JA, Shamah T, Villalpando S, Monterrubio E. Effectiveness of a large-scale iron-fortified milk distribution program on anemia and iron deficiency in low-income young children in Mexico. Am J Clin Nutr 2010;91:431-439.
Rivera JA, Sotres-Alvarez D, Habicht JP, Shamah T, Villalpando S. Impact of the Mexican Program for Education, Health and Nutrition (Progresa) on rates of growth and anemia in infants and young children. A randomized effectiveness study. JAMA 2004;291:2563-2570.
Leroy J, García-Guerra A, Garcia R, Dominguez C, Rivera JA, Neufeld LM. The Oportunidades Program Increases the Linear Growth of Children Enrolled at Young Ages in Urban Mexico. J Nutr 2008; 138:793-798.
Neufeld LM, Mejia F, Fernández Gaxiola AC, García Guerra A, Méndez I, Domínguez CP. Diagnóstico situacional del estado nutricio de niños menores de dos años de edad y de sus madres, beneficiarios de Oportunidades en zonas rurales. En: Evaluación externa del Programa Oportunidades 2008. A diez años de intervención en zonas rurales (1997-2007). Vol 2. El reto de la calidad de los servicios: resultados en salud y nutrición. Cuernavaca: Instituto Nacional de Salud Pública, 2008.
García-Guerra A, Rivera-Dommarco J, Neufeld L, Domínguez-Islas CP. Effect of three supplements with equal micronutrient content on serum zinc concentrations in Mexican children. FASEB J 2009;23:917.13.
Krebs N. Overview of zinc absorption and excretion in the human gastrointestinal tract. J Nutr 2000;130:S1374-S1377.
World Health Organization. Zinc. Vitamin and mineral requirements in human nutrition. Geneva: World Health Organization, 2004:230-245.
Schneider JM, Fujii ML, Lamp CL, Lönnerdal B, Zidenberg-Cherr S. The prevalence of low serum zinc and copper levels and dietary habits associated with serum zinc and copper in 12- to 36-month-old children from low-income families at risk for iron deficiency. J Am Diet Assoc 2007;107:1924-1929.
Rodríguez D, Papale J, Dellan G, Torres M, Berné Y, Mendoza N, et al. Deficiencia de zinc y cobre en menores de 15 años en una población rural de Venezuela. Boletín Médico 2004:20:55-60.
Rosado J. Ingestión dietética recomendada de cobre. En: Bourgues H, Casanueva E, Rosado J, ed. Ingestión de nutrimentos para la población mexicana, bases fisiológicas. México D.F.: Médica Panamericana, 2005:273-280.
Nhien NV, Khan NC, Yabutani T, Ninh NX, Chung le TK, Motonaka J, et al. Relationship of low serum selenium to anemia among primary school children living in rural Vietnam. J Nutr Sci Vitaminol 2008;54:454-459.
Srinivasa-Reddy Y, Pullakhandam R, Radha-Krishna KV, Uday-Kumar P, Dinesh-Kumar B. Lead and essential trace element levels in school children: a cross-sectional study. Ann Hum Biol 2011;38:372-377.