López RLP, Hernández MI, Pascacio SH, Gordillo MK, Cadena AGN, Madrid ZRM

Language: Spanish
References: 13
Page: 30-35
PDF size: 326.03 Kb.

ABSTRACT

Background: Polycystic ovary syndrome is a common endocrine disorder that occurs in 4-7% of women of reproductive age. It is associated with insulin resistance (40%), hyperandrogenemia (75%) and metabolic syndrome, which are the condition that the cause is heterogeneous.
Objective: To determine the correlation insulin resistance, hyperandrogenism, hyperandrogenemia.
Patients and methods: retrospective study based on information from service records of Gynecology-endocrine Juarez Hospital of Mexico. We included 95 patients with polycystic ovary syndrome and glucose-Rotterdam criteria insulin.
Results: The mean age of patients was 26.1 years and the glucose concentrations of 93.5 mg/dL, insulin of 19.2 IU/mL, insulin resistance by HOMA-IR 48%, QUICKY 91 and 74% had overweight or obese and 46.3%-adrenal hyperandrogenemia. The Pearson correlation of HOMA-insulin resistance, total testosterone had a p of 0.049 (95%), 58% phenotype A and Ferriman-Gallwey score of ≥ 8 in 59%.
Conclusions: The correlation between insulin resistance and other androgens was not significant.

REFERENCES

1. Calderón BR, Yanes QM, Lugones BM. Síndrome de insulinorresistencia y síndrome de ovarios poliquísticos: ¿existe relación entre ambos? Revista Cubana de Obstetricia y Ginecología 2009;1(35):1-8.

2. Okan YB, Gedik OL. Resistencia a la insulina en el síndrome de ovario poliquístico: hiperandrogenemia frente a normoandrogenemia. European Journal of Obstetrics & Gynecology and Reproductive Biology 2002;2:114-118.

3. Stanczyk FZ. Diagnosis of hyperandrogenism biochemical Criteria. Best Practice and Research Clinical Endocrinology and Metabolism 2006;2(20):177-191.

4. Del Río MJ, Ramírez JP, Cortés ME, Martí GE, Godoy RA, Vigil PP. Análisis de resistencia insulínica, tolerancia a la glucosa y testosterona en mujeres jóvenes con síndrome de ovario poliquístico agrupadas por índice de masa corporal. Revista Chilena de Obstetricia y Ginecología. 2006;71(5):299-306.

5. Hernández VM, Rosas MH, Zárate A. Atención de la resistencia a la insulina en el síndrome de ovarios poliquisticos. Ginecol Obstet Mex 2010;78(11):612-616.

6. Venkaten AM, Dunaif IF, Corbould AN. Insulin Resistance in Polycystíc Ovary Syndrome: Progress and Paradoxes. Endojournals. Org. 2011;Mayo.

7. Blumel BE, Flores MA, Gonzáles JA, Arraztoa JA. ¿Es el HOMA un instrumento adecuado para diagnóstico de insulino resistencia en pacientes con SOP? Revista Chilena de Obstetricia y Ginecología. 2005;70(5):346-351

8. Carvajal RO, Herrera CR, Porcile AR. Espectro fenotípico del síndrome de ovario poliquístico. Revista Chilena de Ginecología y Obstetricia 2010;75(2):124-132.

9. Fog SP, Madsbad ST, Nilas Ll. The insulln-resistant phenotype of polycystic ovary syndrome. Fertility and Sterility August 2010;3(94):1052-1058.

10. Ulluturk UG, Harmanci AY, Kocaefe CE, et al. The Genetic Basis of the Polycystíc Ovary Syndrome: A Literature Review Including Discussion of PPAR-y. 2007;23:24-42.

11. Dunaif AN. Polycystíc Ovary Syndrome: Mechanism and impiicatíons for pathogenesis.Endocrine Reviews 1997;18(6): 774-800.

12. Ardhana M, Dunaif AN, Corbould AN. Insulin Resistance in Polycystíc Ovary Syndrome progress and paradoxes. Endojournals. 2001;295-307.

13. Qu HQ, Li QU, Rentfo AR, et al. Definit on of Insulin Resistance Using HOMA-IR for Americans of Mexican Descent Using Machine Learning. Mayo Clinic 2011;6:1-4.