Ríos MMP, Patiño GG

Language: Spanish
References: 21
Page: 271-277
PDF size: 306.67 Kb.

ABSTRACT

Background. Nephrotic syndrome (NS) is diagnosed by the presence of massive proteinuria, hypoalbuminemia, edema and hypercholesterolemia. The usual onset is between 2 and 10 years of age. This study was conducted to determine the features of idiopathic NS in patients at an unusual age.
Methods. A retrospective study was carried out in the Nephrology Department at the Pediatrics Hospital, Centro Medico Nacional de Occidente, Guadalajara, Mexico from January 2007-June 2009. Twenty three cases were analyzed to evaluate clinical features, biochemical parameters and histopathological spectrum. Medical management and outcome were established.
Results. We analyzed 10 patients ‹2 years of age and 13 patients ›10 years of age. There were 11 females and 12 males. Mesangial proliferative glomerulonephritis was found in seven (30.4%) patients, diastolic hypertension in 16 (69.5%) patients, hematuria in 15 (65.2%) patients, and positive IgM immunofluorescence in renal biopsy in 13 (56.5%) patients. There were 13 patients who did not achieve remission (56.5%).
Conclusions. There was no gender predominance in idiopathic NS patients with unusual age presentation. Mesangial proliferative glomerulonephritis was the most common histopathological subtype.

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