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2011, Number 5

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Arch Med Actual Trac Gen Inf 2011; 3 (5)

Utilidad de las técnicas moleculares de detección de VPH en el control y prevención del cáncer cervicouterino

Gutiérrez RR

Language: Spanish
References: 64
Page: 16-23
PDF size: 169.32 Kb.


ABSTRACT

Persistent infection with high-risk human papillomaviruses (HPV) has been demonstrated as the necessary causal factor for developing high-grade cervical intraepithelial neoplasia (CIN) and potential progression to cervical cancer. Considering this association it has been proposed the incorporation of highly sensitive and specific HPV detection methods such as DNA HPV test for screening programs. Recently, a great variety of DNA and RNAHPV tests are available, nevertheless, the two major methods for detection of carcinogenic HPV DNA are, hybridization with signal amplification (CH2), and genomic amplification using polymerase chain reaction (PCR); they typically have used a pool of primers for broad-spectrum amplification of HPV DNAfollowed by specific detection of target HPV types using type-specific hybridization probes. PCR-based protocols are highly specific and sensitive and allow the detection of latent and active HPV infection, as well as detection and typing of the specific HPV that causes such infections. The main advantage of these tests is the early detection of high risk lesions NIC II/III and post treatment recurrence this non identified by cytology; can allow lengthen screening intervals in women with negative HPV high-risk test, at the same time, allows more resource investments in the follow up and testing of high risk groups.


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