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2012, Number 1

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Med Crit 2012; 26 (1)

2nd place Winner to Prize «Dr. Mario Shapiro»
Relationship between intensive care admission p50 and mortality

Salgado HTI, Gómez CJME, Cerón DUW

Language: Spanish
References: 10
Page: 11-20
PDF size: 89.43 Kb.


ABSTRACT

In the critically ill patient frequently occur shifts in the oxyhemoglobin dissociation curve (measured by p50). This study analyzes the association among mortality rates, admission value of p50 and deviation related factors.
Material and methods: A cross-sectional and retrospective study was performed with data from patients admitted at the Hospital Español’s ICU between September 2009-June 2011. Patients were categorized according to levels of p50 (‹ 25, 25-29, › 29mmHg), lactate (‹ 2, 2-4, › 4 mmol/L) and pHa (‹ 7.35, 7.35-7.45. › 7.45).
Results: 527 out of 648 patients were included. The observed ICU and hospital mortality rates amongst the p50 subgroups was 8.5%, 12%, 31% («p» ‹ 0.001) and 23%, 22%, 41% («p» ‹ 0.001) respectively; furthermore statistically significant variations in mortality rates occurred for pHa and lactate. Statistically significant variations were found in all p50 subgroups for pHa, lactate, PaCO2, bicarbonate, carboxyhemoglobin and SAPS3 variables.
Conclusions: This study identified ICU and in-hospital mortality rate variations for patients showing deviations in the oxyhemoglobin dissociation curve; intergroups variations for pHa, lactate, PaCO2, carboxyhemoglobin and bicarbonate are consistent with p50 deviations.


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