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Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado

2009, Number 4

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Rev Esp Med Quir 2009; 14 (4)

Feed behavior regulation in an experimental model of anorexia

Gortari P

Language: Spanish
References: 36
Page: 185-190
PDF size: 224.34 Kb.


ABSTRACT

Motivation for feeding depends on the response of the paraventricular nucleus of the hypothalamus that integrates both, central and peripheral signals, and also regulates the neuroendocrine systems. In response to a deficient nutrient availability, neurons that synthesize orexigenic peptides from the lateral hypothalamus, and arcuate nucleus are activated, while those that affect negatively feeding behavior, are inhibited. In consequence, hypothalamic thyrotropin-releasing hormone (TRH) release decreases, thyroid axis is decelerated and degradation of energy deposits is reduced. In spite of the strict control of feeding behavior and the variety of signals that participate on it, some threatening stimuli alter the response of the organism to a negative energy balance, presenting an aberrant anorexic conduct. Using an experimental model submitting animals to stress by dehydration, it is possible to induce a decreased appetite and food intake, as well as a dramatic loss of body weight since the first day of the study. When we compare the thyroid axis function of these animals, to other pair-fed group that is motivated to eat, we observe an activation of the TRHergic neurons of the hypothalamus, exclusively in anorexic animals. Also, we analyzed some possible factors involved in the lack of adaptation of the thyroid axis to low food intake, and the development of an anorexic behavior.


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