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2011, Number 3

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Gac Med Mex 2011; 147 (3)

Factors associated to pulmonary tuberculosis in patients with Diabetes mellitus from Veracruz, México

Pérez-Navarro LM, Fuentes-Domínguez F, Morales-Romero J, Zenteno-Cuevas R

Language: Spanish
References: 26
Page: 219-225
PDF size: 97.37 Kb.


ABSTRACT

In Mexico, 20% of cases of tuberculosis (TB) are associated with diabetes mellitus (DM). However, the behavior of the factors related to this comorbidity is unknown, so the aim of this study was to estimate the risk factors and outcome for TB-DM in a population from the state of Veracruz, Mexico.
We developed a double-design study: cases and controls for the estimation of risk factors, and a retrospective cohort for the outcome factors. The populations surveyed were 67 patients with the comorbidity TB-DB and 109 with TB.
The risk factors for tuberculosis in the diabetic population studied were: age ≥ 35 with an OR of 2.5 (95% CI: 1.4-4.3) and IMC ≥ 25 with an OR of 8.5 (95% CI: 3.1-23.3). According to the outcome variables, the patients with TB-DM showed an increased risk of 2.8 (95% CI: 2.2-3.4) for the development of drug resistance against tuberculosis.
In conclusion, age and overweight are important risk factors, and drug resistance is an important outcome factor for the binomial TB-DM in the population from Veracruz. This information will have important effects on the development of surveillance programs against TB, with emphasis on the characteristics of the diabetic population.


REFERENCES

  1. World Health Organization. REPORT 2009. Global Tuberculosis Control. Epidemiology Strategy Financing. 1.8 Sumary pp.32. Disponible en: http://www.who.int/tb/publications/global_report/2009/en/index.html. [Consultado el 30 de junio de 2010].

  2. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047-53.

  3. Alisjahbana B, Van Crevel R, Sahiratmadja E, et al. Diabetes mellitus is strongly associated with tuberculosis in Indonesia. Int J Tuberc Lung Dis. 2006;10:696-700.

  4. Restrepo B, Fisher-Hoch S, Crespo E, et al. Type 2 diabetes and tuberculosis in a dynamic bi-national border population. Epidemiol Infect. 2007;135:483-91.

  5. Shetty N, Shemko M, VazM, D’Souza G. An epidemiological evaluation of risk factors for tuberculosis in South India: a matched case control study. Int J Tuberc Lung Dis. 2006;10:80-6.

  6. Singla R, Khan N, Al Sharif N, Ai-Sayegh M, Shaikh M, Osman M. Influence of diabetes on manifestations and treatment outcome of pulmonary TB patients. Int J Tuberc Lung Dis. 2006;10:74-9.

  7. Ponce de León A, García-García M, García-Sancho M, et al. Tuberculosis and diabetes in southern México. Diabetes Care. 2004;27:1584-9.

  8. Stevenson CR, Forouhi NG, Gojka R, et al. Diabetes and tuberculosis: the impact of the diabetes epidemic on tuberculosis incidence. BMC Public Health. 2007;7:234.

  9. Tamura M. A study on relation between active pulmonary tuberculosis and underlying diseases. Kekkaku. 2001;76(9):619-24.

  10. Wada M. The effectiveness of pyrazinamide-containing six-month short course chemotherapy. Kekkaku. 2000;75(11):665-73.

  11. Morris J, Seaworth B, McAllister C. Pulmonary tuberculosis in diabetics. Chest. 1992;102:539-41.

  12. Sistema Único de Información para la Vigilancia Epidemiológica. Incidencia de Diabetes mellitus no insulinodependiente (Tipo II) 2006. Dirección General de Epidemiología/SSA, México.

  13. Plataforma única de información en salud. Módulo tuberculosis. Programa de acción para la prevención y control de la tuberculosis. 2009. Veracruz.

  14. American Diabetes Association. Standards of Medical Care in Diabetes 2009. Diabetes Care. 2009;32 Suppl 1:S13-61.

  15. Fuentes J. Programa de acción para la prevención y control de la tuberculosis. 2007. Veracruz. Secretaría de Salud de Veracruz.

  16. Jeon C, Murray M. Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies. PLoS Med, 2008;5(7):e152.

  17. Balde N, Camara A, Camara L, Diallo M, Kake A, Bah-Sow O. Associated tuberculosis and diabetes in Conakry, Guinea: prevalence and clinical characteristics. Int J Tuberc Lung Dis. 2006;10(9):1036-40.

  18. Ezung T, Devi NT, Singh NT, Singh TB. Pulmonary tuberculosis and diabetes mellitus-a study. J Indian Med Assoc. 2002;100(6):376-9.

  19. Delamaire M, Maugendre D, Moreno M, Le Goff MC, Allannic H, Genetet B. Impaired leucocyte functions in diabetic patients. Diabet Med. 1997;14(1):29-34.

  20. Sidibé H. Diabète et tuberculose pilmonaire: aspectos épidémiologiques, physiopathologiques et symptomatologiques. Cahiers Sante. 2007;17(1): 29-32.

  21. Restrepo B. Convergence of the tuberculosis and diabetes epidemics: Renewal of old acquaintances. Clin Infect Dis. 2007;15(4):436-68.

  22. Leung Ch, Lam T, Chan W, et al. Diabetic control and risk of tuberculosis: A cohort study. Am J Epidem. 2008;167(12):1486-94.

  23. Duran V. Diabetes mellitus tipo 2 en adultos con tuberculosis pulmonar. Rev Med IMSS. 2002;40(6):473-6.

  24. Sperli M, Figueredo S, Eli C, Cruz S, Scatena T. Caracterización socioeconómica de la tuberculosis. Rev Latin Enfermagem. 2007;15:1-6.

  25. Restrepo B, Fisher-Hoch S, Pino P, et al. Tuberculosis in poorly controlled type 2 diabetes: Altered cytokine expression in peripheral white blood cells. Clin Infect Dis. 2008;47:634-41.

  26. Bashar M, Alcabes P, Rom W, Condos R. Increased incidence of multidrug-resistant tuberculosis in diabetic patients on the Bellevue Chest Service, 1987 to 1997. Chest. 2001;120:1514-9.




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