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ISSN 0188-9796 (Print)

2010, Number 4

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Rev Endocrinol Nutr 2010; 18 (4)

Vitamin D and type 2 diabetes mellitus

Gómez-Cruz JR

Language: Spanish
References: 46
Page: 186-193
PDF size: 338.88 Kb.


ABSTRACT

The importance of vitamin D in the bone and mineral metabolism is well-known. Recently an accumulation of knowledge has been generated on other actions of vitamin D, in particular on its participation in the metabolism of the glucose. Human and animal studies demonstrated that vitamin D modulates insulin secretion and insulin sensibility. In order to explore the association between the vitamin levels D and the risk of diabetes mellitus (DM) the evidence available was reviewed until the moment, beginning with cross-sectional studies, happening through cohort studies and finishing with the intervention studies, with a brief commentary to near the findings of genetic studies. Observational studies, as cross-sectional and cohort studies demonstrated a consistent and inverse association between the vitamin D levels and the risk of DM, nevertheless the intervention studies present data not so clear, possibly related to the methodology used. This context opens the opportunity to develop new experimental research that responds this association.


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