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ISSN 0188-9796 (Impreso)

2010, Número 4

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Rev Endocrinol Nutr 2010; 18 (4)


Vitamina D y diabetes mellitus tipo 2

Gómez-Cruz JR

Idioma: Español
Referencias bibliográficas: 46
Paginas: 186-193
Archivo PDF: 338.88 Kb.


RESUMEN

La importancia de la vitamina D en el metabolismo óseo y mineral es bien conocida. Recientemente se ha generado un cúmulo de conocimientos sobre otras acciones de la VD, en particular sobre su participación en el metabolismo de la glucosa. Estudios en animales y en humanos demostraron que modula tanto la secreción como la sensibilidad a la insulina. Para explorar la asociación entre los niveles de VD y el riesgo de diabetes mellitus (DM) se revisó la evidencia disponible hasta el momento, empezando con estudios transversales, pasando por estudios de cohortes y terminando con los estudios de intervención, con un breve comentario acerca de los hallazgos de estudios genéticos. Los estudios observacionales, tanto transversales como de cohortes demostraron una asociación consistente e inversa entre los niveles de VD y el riesgo de DM, sin embargo, los estudios de intervención presentan datos no tan claros, posiblemente relacionados con la metodología empleada. Este contexto abre la oportunidad de desarrollar nuevos trabajos prospectivos y experimentales que permitan responder de manera más firme esta asociación.


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