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Patología Revista Latinoamericana

2010, Number 2

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Patol Rev Latinoam 2010; 48 (2)

Differences in pathogenicity of the complex of species Sporothrix in an animal model

Arrillaga MI, Capilla J, Fernández AM, Fariñas F, Mayayo E

Language: Spanish
References: 20
Page: 82-87
PDF size: 309.83 Kb.


ABSTRACT

Background: Three new species of Sporothrix have been recently described within the Sporothrix complex. These species show important genetic and phenotypic differences.
Objectives: To evaluate the differences in pathogenicity, tissue response and morphological type of lesions in experimental sporotrichosis caused by different species.
Material and methods: We performed a comparative study about virulence using a systemic and a subcutaneous model of sporotrichosis in mice caused by S. globosa, S. brasiliensis and S. schenckii.
Results: S. brasiliensis was the most virulent species, and induced high mortality, high fungal load and multiorganic dissemination, with a low inflammatory response and fungal proliferation in all analysed organs. S. schenckii spread to all organs but fungal load was significantly lower than in infection with S. brasiliensis. Cellular response consisted in acute inflammatory activity and formation of granuloma. S. globosa only caused inflammation in inoculated area.
Conclusions: Differences in infection by all three species of Sporothrix were significant and this fact could explain the clinical and pathologic diversity usually observed in human sporotrichosis.


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