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Patología Revista Latinoamericana

2011, Number 2

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Patol Rev Latinoam 2011; 49 (2)

Psammoma bodies and degenerative changes in choroid plexus tumors: clinical-pathological study

Tena SML, Rembao BD, Salinas LC, Vega OR, Castillejos M

Language: Spanish
References: 32
Page: 107-114
PDF size: 565.13 Kb.


ABSTRACT

Background: Choroid plexus papillomas are rare benign tumors, usually have a good outcome after surgery and occur mainly in children.
Objective: To demonstrate through clinical behavior of tumors and monitoring of cases within five years, that there are psammoma bodies and papillary degenerative changes in choroid plexus tumors.
Material and methods: We identified all cases of choroid plexus tumors treated from January 1993 to December 2003. We reviewed the clinical records and the following data were obtained: age, location and tracking. Histologically biopsies of choroid plexus tumors were reviewed. Samples obtained were evaluated by histological type, dystrophic calcification and psammoma bodies associated with inflammation and invasion of surrounding brain tissue. It was related the location and size of the tumor with psammoma bodies, inflammation and degenerative changes or papillae papillary edema and processed data from the statistical program SPSS, version 11.0, Windows®.
Results: We included 37 cases of choroid plexus tumors, 26 were papillomas, and of these, four were considered atypical and 11 were carcinomas. The age ranged from 15 to 85 with an average of 46 years, 27 cases were women and 11 men. Psammoma bodies were demonstrated in 29.7%, of whom 6.2% were papillomas, and 13.5%, carcinomas (p = 0.627), being higher in women than in men (18.9%, p = 0.066). Filtration was found adjacent brain tissue 59.5% and inflammatory infiltrates in 54.1% (p = 0.066). The degenerative changes of the papillae occurred in 40.5% of papillomas and carcinomas in 5.4% (p = 0.031).
Conclusions: The association between inflammatory infiltrate and psammoma bodies is poorly understood, but in our work we found that are more common in women, and recurrences are more frequent in carcinomas than in choroid plexus papillomas, and changes papillary degenerative disorders are higher in papillomas. In relation to the biological behavior of these tumors, we have discussed the existence of psammoma bodies associated with papillary inflammation and degenerative changes.


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