García-Ortiz L, Gutiérrez-Salinas J, Galaviz-Hernández C, Chima-Galán MC, Hilton-Cáceres JM, Escobedo-Aguirre F, Peña-Gutiérrez M, Iniesta-Mejía A, Miranda-Murillo J

Language: Spanish
References: 18
Page: 190-195
PDF size: 352.11 Kb.

ABSTRACT

Background: The preeclampsia is a multisystemic syndrome that occupied the first cause of maternal and fetal mortality around the world. Epidemiologic studies shown both mother and father contribute at the same risk for preeclampsia.
Objective: To determinate if there is an association between preeclampsia and paternal age.
Material and method: Preeclampsia-eclampsia patients and couples were analyzed in agree to “National High Blood Pressure Education Program Working Group” classification, and a control group constituted by normal pregnant women and couples was included.
Results: There were 27 cases with mild preeclampsia and her couples, 13 cases with severe preeclampsia and her couples and 40 controls conformed by normal pregnant women and her couples. The statistical analysis of variance of the ages shown that men from preeclamptic group had a greater variance in contrast with man of control group (p ‹ 0.001; valor ofF = 5.084).
Conclusions: Although is not clear how paternal age interview in preeclampsia risk, the interaction between paternal-maternal imprinting and spermatic senescence, followed by shortened telomeres of chromosome, could be produce the inactivity of a whole network of signals implicated in disease aetiology.

REFERENCES

1. Baker PN, Kingdom J. Pre-eclampsia current perspectives on management. 1st ed. USA: Parthenon; 2004:11.

2. Secretaría de Salud. Boletín de Práctica Médica Efectiva de Preeclampsia/Eclampsia. Salud Pub Mex 2006;1-2.

3. Gómez Bravo TE, Briones Garduño JC, Morales Esquivel JG, Rodríguez Roldán M. Mortalidad materna en el Estado de México. Rev Asoc Mex Med Crit y Ter Int 2003;17:199-203.

4. Lachmeijer AM, Arngrimsson R, Bastiaans EJ, Frigge ML, et al. A genome-wide scan for preeclampsia in the Netherlands. Eur J Hum Genet 2001;9:758-764.

5. Secretaría de Salud. Diagnóstico y Manejo de la Preeclampsia/Eclampsia, Lineamiento Técnico. 4a ed. México: Editorial Secretaría de Salud, 2007;p:60.

6. Wilson R. Recurrent miscarriage and pre-eclampsia. 1a ed. UK: Editorial World Scientific; 2004:103.

7. Vigil-De Gracia P, Reyes W, Rodríguez-Morales F, Cruz-Brencop R. Eclampsia en América Central. Ginecol Obstet Mex 2002;70:545-550.

8. Noguera F, Ayala T, Arredondo F, Allen M. Algunos conceptos sobre preeclampsia-eclampsia y los avances en su evolución por algunas pruebas de laboratorio. Ginecol Obstet Mex 1997;65:300-304.

9. Belfort MA. Hypertension in pregnancy. 1a ed. New York: Marcel Dekker, 2003;381.

10. Li De-Kun, Wi S. Changing paternity and the risk of preeclampsia/eclampsia in the subsequent pregnancy. Am J Epidemiol 2000;151:57-62.

11. Harlap S, Paltier O, Deutch L, Knaanie A, et al. Paternal age and preeclampsia. Epidemiology 2002;13:660-667.

12. Chen XK, Wen SW, Krewski D, Fleming N, et al. Paternal age and adverse birth outcomes: teenager or 40+, who is at risk? Hum Reprod 2008;23:1290-1296.

13. Sibai B. Hypertensive disorders in women. 1a ed. USA: WB Saunders; 2001;262.

14. Bates DM. Nonlinear regression analysis and its applications. 3a ed. New York: Wiley; 1988;234.

15. Cornish K. An introduction to using statistics in research. 1a ed. USA: Trend Focus Group; 1998;80.

16. Wagschal A, Feil R. Genomic imprinting in the placenta. Cytogenet Genome Res 2006;113:90-98.

17. Arnaud P, Feil R. Epigenetic deregulation of genomic imprinting in human disorders and following assisted reproduction. Birth Defects Res C Embryo Today 2005;75:81-97.