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2011, Number 1

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Enf Infec Microbiol 2011; 31 (1)

Role of nitric oxide (NO) in Malaria

Herrera OA

Language: Spanish
References: 39
Page: 26-32
PDF size: 173.26 Kb.


ABSTRACT

Malaria is a disease caused by infection of the parasite of the genusPlasmodium, with 4 species that cause disease in humans, P. vivax, P. falciparum, P. ovalae, and P. malariae. This disease is a major public health concern, causing more deaths than any other global parasitic disease, about 1.5 to 2.7 million deaths each year. Studies of Plasmodium infection have provided important information on the role of nitric oxide (NO) on defense against parasite. NO is a molecule that comprises a complex biological function, participating in various events, including those involved in immune response. In the development of malaria it has not been shown to have important functions and has been proposed as a crucial molecule in the malaria pathogenesis, but its mechanism of action for the disease is controversial. On the one hand, there is evidence that it aids in the death of the parasite, whereas other studies support its role in the pathogenesis of the disease. Furthermore, NO is also involved in the immune response of the Anopheles mosquito, transmitter of the parasite. This paper presents an overview of the involvement of NO in the immune response and pathogenesis of malaria in humans, and particularly the role of this molecule in the immune response of mosquitoes.


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