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2004, Number 2

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Cir Cir 2004; 72 (2)

Familiar mediterranean fever in Mexico City. A 20-year follow-up

Halabe-Cherem J, Pérez-Jiménez C, Nellen-Hummel H, Mercado-Atri M, Sigala-Rodríguez C, Castañón-González J

Language: Spanish
References: 9
Page: 135-138
PDF size: 40.35 Kb.


ABSTRACT

Familial Mediterranean fever (MFF) is an autosomic recessive, inherited inflammatory disease principally seen in persons from the Mediterranean area. Clinical findings include fever, abdominal pain, and pleuritis. The most severe complication of MFF is renal amiloidosis, manifested as nephrotic syndrome, which evolves into chronic renal failure. In this study, we described clinical findings, evolution, and response to treatment in 52 patients diagnosed with MFF living in Mexico City in whom the most important clinical features were fever and abdominal pain. Differing from previous reported series of patients from the Mediterranean area, patient developed renal amiloidosis during the 20-year follow-up, which suggests that an environmental factor might have a significant influence in development of renal amiloidosis


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