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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2010, Number 3

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Rev Biomed 2010; 21 (3)

Current status of Dengue Vaccines. Perspectives

Zambrano-Mora BM

Language: Spanish
References: 40
Page: 197-211
PDF size: 348.04 Kb.


ABSTRACT

Dengue fever continues spreading beyond tropical and sub-tropical regions and it became an increasing Public Health issue in endemic areas, with an important growing in its incidence and mortality. Control measures have not been enough and specific means of treatment and prevention are still not available. Advances in dengue vaccines design through innovative technologies have been made in the last decades. Most of theses vaccines are in pre-clinical stages of development and only some of them have reached clinical stages, with promising results. It is expected to have available a dengue vaccine in the near future, that may complement the existing strategies of control disease. This is a review on the current status of vaccines in development. Besides, it is included some information on guidelines coordinated by the WHO to conduct clinical trials, and regulatory aspects to be considered for the future license of these dengue vaccines.


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