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Colegio de Medicina Interna de México.

2011, Number 1

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Med Int Mex 2011; 27 (1)

Tratamiento con terapia biológica en enfermedades reumatológicas y su relación con tuberculosis

Barragán-Garfias JA

Language: Spanish
References: 34
Page: 52-57
PDF size: 344.43 Kb.


ABSTRACT

The implementation of biological therapy (or biotherapy) against tumour necrosis factor of certain connective tissue diseases, such as Rheumatoid Arthritis and seronegative spondyloarthropathies in the domain of Rheumatology, psoriasis in Dermatology and inflammatory bowel disease in Gastroenterology, have become a keystone to change the evolution of these conditions and to have an alternate treatment when no clinical response is shown to first line treatments, for which several studies have proven to be effective. Nevertheless, since the implementation of biotherapy on anti-tumour necrosis factor antibodies (anti-TNF), patients receiving such treatment have been reported to experience an increased incidence of pulmonary and extrapulmonary tuberculosis. Hence, it is important to perform a proper research protocol prior to the anti-TNF antibody treatment in order to screen the latent tuberculosis, thereby decreasing the risk of reactivation of this condition.


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