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Órgano Oficial del Instituto de Ciencias de la Salud, Hospital Escuela y Facultad de Medicina-Xalapa

2009, Number 1

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Rev Med UV 2009; 9 (1)

Prolactin: Intracellular mechanisms involved in prostatic function

Pacual MLI, Manzo DJ, Goffi V, Kessal K, Aranda-Abreu GE, Estudillo CA, Hernández AM

Language: Spanish
References: 20
Page: 36-40
PDF size: 801.63 Kb.


ABSTRACT

Prolactin (PRL) is a proteinic hormone that has been related to over 300 diff erent physiological functions, nonetheless, its involvement in the synthesis of milk by the mammary gland is best known. Its function is carried out throw the binding to specific membrane receptors, the PRL (RPRL), and it reported the existence of 3 diff erent isoforms called long, intermediate and short. Their density and type vary depending on the hormonal and physiological state of the subject, which suggests that the variable abundance of these isoforms is involved with specific functions within each of the tissues.
The binding prolactin-receptor produces the activation of different intracellular signaling forms, among which are found the STAT (Signal transducers and Transcription Activators) an MAP kynase (kynase proteins activated by mitogens), that are involved in the diff erentiation and cellular proliferation process. In the prostate, it is known that PRL intervenes in the synthesis of Catepsin-D, androgen and citrate as well as in the increase in the quantity of semen in response to sexual stimuli. It has also been observed that it has some part in the ethiology of pathologies (Prostatic Hyperplasia). Even though PRL activates different signaling pathways and that it is involved in normal and pathological functions, the relation among these is still not clear. Therefore, this review intends to clarify the relation between the intracellular pathways used by PRL and the functions in which this hormone takes part.


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