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Federación Mexicana de Ginecología y Obstetricia, A.C.

2009, Number 09

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Ginecol Obstet Mex 2009; 77 (09)

Sphingolipds in embryonic implantation

Espinosa CR

Language: Spanish
References: 22
Page: 428-435
PDF size: 508.85 Kb.


ABSTRACT

Embryonic implantation is a complex series of processes that establishes the connection between maternal and embryonic tissues and requires an intricate program of uterine preparation. During early gestation in invasively implanting species, the uterine stromal compartment undergoes dramatic remodeling, defined by the differentiation of stromal fibroblast cells into decidual cells. Lipid signaling molecules from a number of pathways are well-established functional components of this decidualization reaction. The decidua provides a vascular network for nutrition and gas exchange for the developing embryo before a functional placenta is established. Because of a correlation in the events that transpire in the uterus during early implantation with known functions of bioactive sphingolipid metabolites established from studies in other organ systems, we hypothesized that uterine sphingolipid metabolism would change during implantation Thus, sphingolipid metabolism regulates proper uterine decidualization and blood vessel stability. The findings also suggest that disturbance in sphingolipid metabolism may be considered as a cause of pregnancy loss in humans.


REFERENCES

  1. Skaznik-Wikiel ME, Kaneko-Tarui T, Kashiwagi A, Pru JK. Sphingosine-1-phosphate receptor expression and signaling correlate with uterine prostaglandin-endoperoxide synthase 2 expression and angiogenesis during early pregnancy. Biol Reprod 2006;74:569-76.

  2. Dey SK, Lim, H, Das SK, Reese J, et al. Molecular cues to implantation. Endocr Rev 2004;25(3):341-73.

  3. Kaneko-Tarui T, Zhang L, Austin KJ, Henkes LE. Maternal and embryonic control of uterine sphingolipid-metabolizing enzymes during murine embryo implantation. Biol Reprod 2007;77:658-65.

  4. Suomalainen L, Hakala JK, Pentikäinen V, Otala, M, et al. Sphingosine-1-phosphate in inhibition of male germ cell apoptosis in the human testis. J Clin Endocrinol Metab 2003;88(11):5572-9.

  5. Savtchouk IA, Mattie FJ, Ollis AA. Ceramide: from embryos to tumors. Science 2007;(394):1-3.

  6. Hannun YA, Obeid LM. The ceramide-centric universe of lipidmediated cell regulation: stress encounters of the lipid kind. The J Biol Chem 2002;277(29):25847-50.

  7. Merrill AH, Jones DD. An update of the enzymology and regulation of sphingomyelin metabolism. Biochim Biophys Acta 1990;1044:1-12.

  8. Huwiler A, Kolter T, Pfeilschifter J, Sandhoff K. Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochim Biophys Acta 2000;1485:63-99.

  9. Ohanian J, Ohanian V. Sphingolipids in mammalian cell signaling. Cell Mol Life Sci 2001:58;2053-68.

  10. Espinosa CR, Rosado GA. Angiogénesis en la fisiología reproductiva. Desarrollo folicular, formación y mantenimiento del cuerpo lúteo. Ginecol Obstet Mex 2002;70:17-27.

  11. Tan J, Raja S, Davis MK, Tawfik O, et al. Evidence for coordinated interaction of cyclin D3 with p21 and cdk6 in directing the development of uterine stromal cell decidualization and polyploidy during implantation. Mech Dev 2002;111(1-2):99-113.

  12. Mizugishi K, Li C, Olivera A, Bielawski J, et al. Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice. J Clin Invest 2007;(10):2993-3006.

  13. Tilly JL, Kolesnick RN. Realizing the promise of apoptosisbased therapies: separating the living from the clinically undead. Cell Death Differ 2003;10:493-5.

  14. Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer2004;4:604-16.

  15. Siskind LJ, Fluss S, Bui M, Colombini M. Sphingosine forms hannels in membranes that differ greatly from those formed by ceramide. J Bioenerg Biomembr 2005;37:227-36.

  16. Cremesti A, Paris F, Grassme H, Holler N et al. Ceramide enables Fas to cap and kill. J Biol Chem 2001;276:23954-61.

  17. Eliyahu E, Park J-H, Shtraizent N, He X, et al. Acid ceramidase is a novel factor required for early embryo survival. FASEB J 2007;21:1403-9.

  18. Perez GI, Jurisicova A, Matikainen T, Moriyama T, et al. A central role for ceramide in the age-related acceleration of apoptosis in the female germline. FASEB J 2005;862(19):860-62.

  19. Morita Y, Perez GI, Paris F, Miranda SR, et al. Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. Nat Med 2000;6:1109-14.

  20. Casper RF, Jurisicova A. Protecting the female germ line from cancer therapy. Nat Med 2000;6(10):1100-1.

  21. Roth Z, Hansen PJ. Sphingosine 1-phosphate protects bovine oocytes from heat shock during maturation. Biol Reprod 2004;71:2072-8.

  22. Spiegel S, Kolesnick R. Sphingosine 1-phosphate as a therapeutic agent. Leukemia 2002;16:1596-602.




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