Pinto CJC, Chávez CD, Morales SE, Salas GG, Sánchez AAC, Valencia MP

Language: Spanish
References: 18
Page: 341-345
PDF size: 287.95 Kb.

ABSTRACT

Amyloidosis is characterized by deposits of an insoluble fibrilar glycoproteins derived from different types of precursor proteins; clinically is classified as generalized or local. The systemic form or amyloidosis is sub-classified as primary amyloidosis associated with dyscrasias of immunocytes or secondary amyloidosis related to chronic diseases. We present two cases of systemic amyloidosis in two Sharpei dogs aged 6 and 7 years whit chronic renal damage. The histologic renal lesions in both cases showed interstitial nephritis rich in plasmatic cells and extensive deposits of amyloid. In the liver, pancreas, lungs, central nervous system and spleen variables amounts o amyloid deposits were also observed. Generalized amyloidosis was probably secondary to chronic renal damage related to Leptospira sp infection in case one, while in case two amyloidosis was perhaps inherited.

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