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2007, Number 1

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Enf Infec Microbiol 2007; 27 (1)

Biofilm: Latent Threat or Protective Factor? State of Art

Diemond HJBB, Miranda NG

Language: Spanish
References: 34
Page: 22-28
PDF size: 129.14 Kb.


ABSTRACT

The study of the pathogenesis of Staphylococcus, includes biofilm as a virulence factor. It has received great interest in recent years, mainly related to the high frequency of infections associated to plastic devices, the high costs of the infections, and the elevated risk of complications in these patients, in part attributed to a bad therapeutic response in the presence of biofilm
The molecular structure of biofilm has been described, along with the pathway of production, the responsible genes involved in its expression and the mechanisms of regulation. Some studies include induction by chemicals and in vitro interactions with the mechanisms of defense of the host and antimicrobials. Despite the number of publications; the clinical relevance and the prognostic implications regarding the response to treatment and its role in the adherence to the plastic device remains to be defined.
We performed a review of the literature, analyze the results of published studies and compared them with our assays with Staphylococcus spp. isolated from pediatric patients.


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