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2007, Número 1

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Enf Infec Microbiol 2007; 27 (1)


Biofilm: ¿amenaza latente o factor de protección? Estado del arte

Diemond HJBB, Miranda NG

Idioma: Español
Referencias bibliográficas: 34
Paginas: 22-28
Archivo PDF: 129.14 Kb.


RESUMEN

Dentro del estudio de la patogenia de los Staphylococcus, el biofilm como factor de virulencia ha recibido gran atención en los últimos años, debido a la elevada incidencia de infecciones relacionadas a dispositivos plásticos, al incremento en los costos de la atención y el aumento del riesgo de complicaciones en estos pacientes, lo cual se atribuye a una respuesta inadecuada al tratamiento antimicrobiano ante la presencia de biofilm.
Actualmente, se ha caracterizado la estructura molecular del biofilm, los genes que codifican la información para su expresión, los genes responsables de su regulación, los químicos que lo inducen y su interacción in vitro con los mecanismos de defensa del cuerpo y con los antimicrobianos. Sin embargo, aún no se determina su importancia en la clínica y los efectos pronósticos sobre la respuesta terapéutica y la persistencia y uso del dispositivo plástico.
Se revisó la literatura sobre este tema, se exponen los resultados descritos en algunos estudios y se comparan con los obtenidos con Staphylococcus spp. aislados de pacientes pediátricos.


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