2007, Number 1
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Enf Infec Microbiol 2007; 27 (1)
Clinic and epidemiological characteristics of patients with infectious endocarditis attended in a Pediatric Hospital
Peña HP, López EJ, Huerta GG, Solórzano SF
Language: Spanish
References: 37
Page: 11-15
PDF size: 82.08 Kb.
ABSTRACT
Objective. To describe clinic and epidemiological characteristics of patients with infectious endocarditis attended since 1991 to 1995 in a third care Pediatric Hospital.
Material and Methods. We search and evaluated pediatric patients files (NB- 15 years) with diagnosis on infectious endocarditis.
Results. 18 patients with confirmed diagnosis of IE were included, there was male predominance (3.5:1), 44% infants (n=18), 28% scholars, 22% toddlers y 5% new born. Of the total of patients, 39% had some cardiac defect, IVD (intraventricular communication) was the most frequent (57%) followed by CAP (22%). Twelve patients had central venous line before or during diagnosis.
Staphylococcus genera was the most frequent organisms identified (6
Staphylococcus coagulasa negative & 3
S. aureus), Gram negative bacteria was isolated in three patients, and fungi in two patients (
Candida sp &
Aspergillus), 27.7% of the blood cultures were negative. Fever, murmurs and gastro-intestinal (94, 94, and 55.5% respectively) were the most frequent manifestations found. 50% of the patients died, and cardiac failure was the first cause of dead. None of the patients need surgery.
Conclusions. This study shows the predominance of infants as the most frequent group affected, and the high frequency of
Staphylococcus. The incidence of this pathology is increasing due to the advances in surgery for congenital cardiovascular defects and the common use of intravascular devices in the last decades.
REFERENCES
Scheld MW and Sande AM. Endocarditis and intravascular infections. En Mandell LG, Gordon DR and Bennett EJ, Infectious diseases and practice. New York, 1979: 653-690.
Tsai W, Klein B. The Postoperative Cardiac Patient. Clin Ped Emerg Med 6: 216-221.
Kumate J y Gutiérrez G. Endocarditis Infecciosa. En Kumate J y Gutiérrez G, Manual de infectología. Francisco Méndez Cervantes, México, 1994: 401-409.
Starke RJ. Infective Endocarditis. En Feigin RD y Cherry DJ, Texbook of pediatric infectious diseases. Philadelphia: W.B. Sauders Company, 1992: 326-346.
Gregoratos G y Karliner SJ. Endocarditis infecciosa. Diagnóstico y tratamiento. En Clínicas Pediátricas de Norteamérica. México, Nueva Editorial Interamericana, 1979: 171-197.
Bayer SA. Infective Endocarditis. Clin Infect Dis 1993; 17: 313-322.
Mendelsohn G, Hutchisns MG. Infective endocarditis during the first decade of life. Am J Dis Child 1979; 133: 619-622.
Harris SL. Definitions and demographic characteristic. En. Kaye D (ed). Infective endocarditis, New York: Raven Press; 1998: 1.
Díaz DC, Vígil G, Rodríguez GF, Martínez BR, Palacios MX. Endocarditis infecciosa de válvulas cardiacas y prótesis valvulares. Reporte de 21 casos. Arch Inst Cardiol Máx 1982; 52: 169-174.
Salman L, Prince A and Gersony MW. Pediatric Infective. Endocarditis in the moderm era. J Pediatr 1993; 122: 847-853.
Ocallaghan C and Mcdougall P. Infective endocarditis in neonatos. Arch Dis Child 1988; 63: 53-57.
Megran WD. Enterococcal Endocarditis. Clin Infect Dis 1992; 15: 63-71.
Graninger W and Rangette R. Nosocomial bacteremia due to Enterococcus faecalis without endocarditis. Clin Infect Dis 1992; 15: 49-57.
Jemsek GJ, Greenberg BS, Gentry OL, Welton ED and Mattox LK. Hnemophilus parainfluenzae endocarditis. Amj Med. 1979; 66: 51-57.
Pollock AA y Holzman SR. Neisseria catarrhalis endocarditis. Ann Intern Med 1979; 85: 206-207.
Pacheco RA, Araujo HL, Cashat CM, Samudio DG, Ávila FC y Santos JI. Endocarditis por cándida en el primer año de vida. Bol Med Hosp. Infant Mex 1993; 50: 157-161.
Blumberg AE, Robbins N, Adimora A and Low DF. Persisten fecer in association with infective endocarditis. Clin Infect Dis 1992; 15: 983-990.
Martin JM, Neches WH, Wald ER. Infective Endocarditis: 35 years of experience at a children´s hospital. Clin Infect Dis 1997; 24: 669-675.
Rubinstein E, Lang R. Fungal endocarditis. Eur Heart J 1995; 16 (Supl B): 84-89.
Weinstein L, Schlesinger J. Pathonatomic, pathophysiologic and clinical correlations in endocarditis. N Engl J Med 1974; 17: 832-837.
Berkowitz EF. Infective Endocarditis. En Nighols GD, Cameron D, Greeley W. Critical care diseases in infant and children. The Mosby, 1995: 961-987.
Zuberbuhler RJ, Neches HW and Park CS. Infectius endocarditis an experience apanning three decades. Cardiol Young 1994; 4: 244-251.
Robbins JM, Soeiro RM, Frishman HW and Strom AJ. Right-sided valvular endocarditis: etiology, diagnosis, and an approach to therapy. Am Heart J 1984; 111: 128-135.
Varma MP, Cluskey MC, Cleland J, Kane OH and Adgey JA. Heart failere associated with infective endoarditis. A review of 40 cases. Br Heart J 1986; 55: 191-197.
Bayer SA, Ward IJ, Ginzton EI and Saphiro MS. Evaluation of new clinical criteria for the diagnosis of infective endocarditis. Am J Medicine 1994; 96: 211-219.
Durack TD, Lukes SA, Bright KD and Duke. New criteria for diagnosis of infective endocarditis utilization of specific echocardiographic findings. Am J Medicine 1994; 96: 200-209.
Rastogi A, Luken AJ, Pildes SR, Chrystof D and Labranche F. Endocarditis en neonatal intensive care unit. Pediatric Cardiology 1993; 14: 183-186.
Zenker NP, Rosenberg ME, Van Dyke BR, Rabalais PG and Daum SR. Successful medical treatment of presumed Candida endocarditis in critically ill infants. J Pediatr 1991; 119: 472-477.
Corono RC. Endocarditis infecciosa. Criterios quirúrgicos. Criterios pediátricos 1993; 16: 85-6.
Tolan WR, Klleiman BM, Frank M, King H and Brown WY. Operative intervention in active endocarditis in children: report of a series of cases and review. Clin Infect Dis 1992; 14: 852-862.
Mansur JM, Griberg M, Lemus LP and Bellotti G. The complications of infective endocarditis. N Engl J Med 1992; 152: 2428-2432.
Ferrieri P, Gewitz M, Gerber M, et al. Unique Features of Infective Endocartitis in childhood. Circulation 2002; 105: 2115-2127.
John MD, Hibberd PL, Karchmer AW, Sleeper LA, Calderwood SB. Staphylococcus aureus prosthetic valve endocarditis: optimal management and risk factors for death. Clin Infec Dis 1998; 26: 1302-1309.
Saiman L, Prince A, Gersony WM. Pediatric infective endocarditis in the modern era. J Pediatr 1993; 122: 847-853.
Smith MJ, Zaoutis TE. Device-related Infections in Children Pediatr. Clin N Am 2005; 52: 1189-1208.
Bouza E, Menasalvas A, Munoz P, et al. Infective endocarditis- a prospective study at the end of the twentieth century: new predisposing conditions, new etiologic agents, and still a high mortality. Medicine 2001; 80: 298-307.
Gouello JP, Asfar P, Brenet O, et al. Nosocomial endocarditis in the intensive care unit: an analysis of 22 cases. Crit Care Med 2000; 28: 377-382.