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Instituto Nacional de Neurología y Neurocirugía

2010, Number 1

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Arch Neurocien 2010; 15 (1)

Role of mitochondrial function in neurodegenerative diseases

Rodríguez-Violante M, Cervantes-Arriaga A, Vargas-Cañas S, Corona T

Language: Spanish
References: 71
Page: 39-46
PDF size: 113.91 Kb.


ABSTRACT

Mitochondria main function is cellular respiration. In recent years the study of the role of the mitochondria in ageing and disease pathophysiology has increased providing new knowledge in animal models as well as in human beings. Objective: in this review we present a brief descritption of the mitocondria, its DNA and its role in ageing and in particular in neurodegenrative diseases. Method: along the review we cover the mitochondrial function and dysfunction in neurodegenerative diseases such as Huntington, Parkinson, Alzheimer and amyotrophic lateral sclerosis emphasizing on recent advances. Conclusion: the mitochondria plays a relevant role in the pathogenesis of various neurodegenerative diseases, the understanding of the cellular mechanisms involved would allow the development of new therapeutic interventions.


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