medigraphic.com
Instituto Nacional de Neurología y Neurocirugía

2009, Number 4

<< Back Next >>

Arch Neurocien 2009; 14 (4)

Adults cerebral sarcoma

Montes MIA, Salinas LC, Rembao BD, Castillejos M, Moreno S, Vega R, Tena SML

Language: Spanish
References: 20
Page: 243-248
PDF size: 200.97 Kb.


ABSTRACT

Brain sarcomas are very rare tumors which correspond to the ‹ 1% of primary tumors and 5-15% of the head and neck tumors. Objective: access the prevalence of brain sarcomas in a single institution. Material and methods: In the neuropathology department, we checked the brain sarcomas of 16 years, between 1990 and 2006. Files were checked and the slides were H&E stained. The clinical-pathological findings were correlated. Results: we studied 35 cases of patients histopathologically diagnosed as brain sarcomas, from which 32 (91.4%) were primary from the nervous system and 3 were metastatic (8.6%). The age was from 16 to 83 years (45.9), 16 cases were women (45.7%) and 19, men (54.3%). Due to the histological type they were: fibrosarcoma 11 (31.4%), reticulo-sarcoma were 5 (14.3%) meningosarcoma were 4 (11.4%) osteosarcoma, malignant fibrous histiocytoma and rhabdomyosarcoma were 3(8.6%), chondrosarcoma and lyposarcoma were 2 (5.7%), Edwing tumor and malignant shwannoma were 1 (2.9%). Relapses were present in 22 cases (62.9%), radiotherapy was given to 24 (68.6%) and chemotherapy to 11 (31.4%). The final evolution of the patients was: with clinical improvement in 17 cases (48.6%), no improvement in 9 (25.7%) and worsening in 9 (25.7%) and 6 (17.1%) had metastasis. There was no relation between total Exerésis and relapse (p=0.631), or with the final evolution of patients. Conclusion: In general, sarcomas have no predilection for .pender and present an age distribution depending on the histological type, however, there are characteristic tumors for certain ages. Because of its location, most of them are supratentorial.


REFERENCES

  1. Abbott KH, Kernohan JW. Primary sarcomas of the brain: review of the literature and report of twelve cases. Arch Neurol Psychiat 1943; 40: 43-66.

  2. Bailey P. Intracranial sarcomatous tumors of leptomeningeal origin. Arch Surg 1929; 18;1359-402.

  3. Zülch KJ. Brain tumors their biology and pathology. New York Springer Publishing Company. Inc 1957.

  4. Budka H, Pilz P, Guseo A. Primary leptomeningeal sarcomatosis. Clinicopathological report of six cases. J Neurol 1975;211-77- 93.

  5. Kernohan JW, Uihlein A. sarcomas of the brain Springfield III, Charls Thomas. 1962.

  6. Merimsky O, Lepechoux C, Terrier P, Vanel D, Delord JP, LeCesne A. Primary sarcomas pf the central nervous system. Oncology 2000; 58: 210-14.

  7. Louis DN, Scheithauer BW, Budka H, von Deimling A, Kepes J. Meningiomioma. En: Kleihues P and Cavenee W (eds). Pathology and genetics of tumors of the nervous system. Lyon, international agency for research of cancer. 2000.

  8. Parker JR, Zarabi M, Parker JC. Intracerebral mesenchymal chondrosarcoma, Ann Clin Lab Scí 1989; 19: 401-7.

  9. Paulus W, Scheithauer BW. Mesenchymal, non meningothelial tumors in Kleihues P and Cavenee WK (eds) Pathology and genetics of the nervous central tumors, lyon Internacional agency on cancer 2000; 185-9.

  10. Paulus W, Peiffer J, Grote E. Malignant fibrous histicytona at site of previous excised Iow grade glioma. Acta Neurochirur 1989; 99: 161-5.

  11. Paulus W, Slowik E, Jellinger K. Primary intracranial sarcomas histopathological features of 19 cases. Histopathology 1991; 18: 395-402.

  12. Rosenberg AE, Nielsen GP, Keel SB. Chondrosarcomas of the base of the skull, a clinicopathologic study of 200 cases with emphasis on its distinction from chordoma. Am J Pathol 1999; 23:1370-8.

  13. 13.Rubinstein JL, Lucien J. Sarcomas of the nervous system; In Minker J. pathology of the nervous system. Vol 2 New York McGraw-Hill. 1971.

  14. Russell DS, Rubinstein JL. Pathology of tumors of the nervous system. 5th (ed) Baltimore, Williams and Wilkins. 1989.

  15. Oliveira AM, Scheithauer BW, Solomao DR, Parisi JE, Burger P, Nascimiento AG. Primary sarcomas of the brain and spinal cord, a study of 18 cases. Am J Surg Pathol 2002; 26: 1056-63.

  16. Deyrup AT, Montag AG, lnwards CY, Xu Z, Swee RG, Krishnan Unni K. Sarcomas arising in Paget disease of bone: a clinicopathologic analysis of 70 cases. Arch Pathol Lab Med. 2007;131:942-6.

  17. de Bree R, Van der Valk P, Kuik DJ, van Diest PD, Buter J, Eerenstein SEJ, et al. Pronostic factors in adults soft tissue sarcoma of the head and neck: a single-centre experience. Oral Oncolol 2006; 42;703-9.

  18. Leinung S, Mobius C, Udelnow A, Hauss J, Wurl P. Histopathological outcome of 597 isolated soft tissue tumors suspected of soft tissue sarcoma: a single-center 12- year experience. Eur J Surg Oncol 2007; 33:508-11.

  19. Al-Nafussi A. Practical morphological approach to the diagnosis and differentiatial diagnosis of soft sarcomas. Curr Diagn Pathol 2002; 8:395-411.

  20. Fisher C, Thway K. Pathology of the soft tissue. Surgery 2006; 24; 402-6.




2020     |     www.medigraphic.com