medigraphic.com
Instituto Nacional de Salud Pública

2010, Number 5

<< Back Next >>

salud publica mex 2010; 52 (5)

Fumonisin intake and human health

Torres-Sánchez L, López-Carrillo L

Language: Spanish
References: 42
Page: 461-467
PDF size: 130.77 Kb.


ABSTRACT

Fumonisins are mycotoxins that contaminate maize, disrupt the folate and sphingolipid metabolism, are associated with neural tube defects, and are considered by the International Agency for Research on Cancer (IARC) as possible human carcinogens. Since maize-based foods are significant components of the Mexican diet and there is a high prevalence of genetic susceptibility for folate deficiency among Mexicans, this essay presents international and national evidence of fumonisin exposure and the relevance that such exposure represents for Mexico.


REFERENCES

  1. Marasas WF. Discovery and occurrence of the fumonisins: a historical perspective. Environ Health Perspect 2001;109 Suppl 2:239-243.

  2. Dombrink-Kurtzman MA, Dvorak TJ. Fumonisin content in masa and tortillas from Mexico. J Agric Food Chem 1999;47:622-627.

  3. Stockmann-Juvala H, Savolainen K. A review of the toxic effects and mechanisms of action of fumonisin B1. Hum Exp Toxicol 2008;27:799-809.

  4. Ariño A, Herrera M, Juan T, Estopañan G, Carramiñana JJ, Rota C, et al. Influence of agricultural practices on the contamination of maize by fumonisin mycotoxins. J Food Prot 2009;72:898-902.

  5. David-Miller J. Factors That Affect the Occurrence of Fumonisin.Environ Health Perspect 2001;109(suppl 2):321-324.

  6. Dombrink-Kurtzman MA, Dvorak TJ, Barron ME, Rooney LW. Effect of nixtamalization (Alkaline cooking) on fumonisin-contaminated corn for production of masa and tortillas. J Agric Food Chem 2000;48:5781-5786.

  7. De La Campa R, Miller JD, Hendricks K. Fumonisin in tortillas produced in small-scale facilities and effect of traditional masa production methods on this mycotoxin. J Agric Food Chem 2004;52:4432-4437.

  8. Sydenham EW, Stockenström S, Thiel PG, Shephard GS, Koch KR, Marasas WFO. Potential of alkaline hydrolysis for removal of fumonisins from contaminated corns. J Agric Food Chem 1985;43:1198-1201.

  9. Scudamore KA, Guy RC, Kelleher B, MacDonald SJ. Fate of Fusarium mycotoxins in maize flour and grits during extrusion cooking. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2008;25:1374-1384.

  10. Shephard GS, Marasas WF, Burger HM, Somdyala NI, Rheeder JP, Van der Westhuizen L, et al. Exposure assessment for fumonisins in the former Transkei region of South Africa. Food Addit Contam 2007;24:621-629.

  11. World Health Organization 2002. Evaluation of certain mycotoxins in food. Fifty-sixth report of the joint FAO/WHO expert committee on food additives (JECFA). WHO technical report 906: 16-27.

  12. Abdel-Nour AM, Ringot D, Guéant JL, Chango A. Folate receptor and human reduced folate carrier expression in HepG2 cell line exposed to fumonisin B1 and folate deficiency. Carcinogenesis 2007;28:2291-2297.

  13. Merrill AH Jr, Schmelz EM, Wang E, Dillehay DL, Rice LG, Meredith F, et al. Importance of sphingolipids and inhibitors of sphingolipid metabolism as components of animal diets. J Nutr 1997;127(5 Suppl):830S-833S.

  14. Marasas WF, Riley RT, Hendricks KA, Stevens VL, Sadler TW, Gelineauvan Waes J, et al. Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize. J Nutr 2004;134:711-716.

  15. Turner PC, Nikiema P, Wild CP. Fumonisin contamination of food: progress in development of biomarkers to better assess human health risks. Mutat Res 1999;443:81-93.

  16. Wild CP, Gong YY. Mycotoxins and human disease: a largely ignored global health issue. Carcinogenesis 2010;31:71-82.

  17. Gong YY, Torres-Sanchez L, Lopez-Carrillo L, Peng JH, Sutcliffe AE, White KL, et al. Association between tortilla consumption and human urinary fumonisin B1 levels in a Mexican population. Cancer Epidemiol Biomarkers Prev 2008;17:688-694.

  18. Constable PD, Smith GW, Rottinghaus GE, Haschek WM. Ingestion of fumonisin B1-containing culture material decreases cardiac contractility and mechanical efficiency in swine. Toxicol Appl Pharmacol 2000;162:151-160.

  19. Gelineau-van Waes J, Voss KA, Stevens VL, Speer MC, Riley RT. Chapter 5 maternal fumonisin exposure as a risk factor for neural tube defects. Adv Food Nutr Res 2009;56:145-181.

  20. Abnet CC, Borkowf CB, Qiao YL, Albert PS, Wang E, Merrill AH Jr, et al. Sphingolipids as biomarkers of fumonisin exposure and risk of esophageal squamous cell carcinoma in china. Cancer Causes Control 2001;12(9):821-828.

  21. Wang Z, Tang L, Sun G, Tang Y, Xie Y, Wang S, et al. Etiological study of esophageal squamous cell carcinoma in an endemic region: a populationbased case control study in Huaian, China. BMC Cancer 2006;6:287.

  22. Missmer SA, Suarez L, Felkner M, Wang E, Merrill AH Jr, Rothman KJ, et al. Exposure to fumonisins and the occurrence of neural tube defects along the Texas-Mexico border. Environ Health Perspect 2006;114:237-241.

  23. Vega-Valdivia DD, Ramírez-Moreno P. Situación y perspectivas del maíz en México. [Monografía en internet] México DF: Universidad Autónoma de Chapingo, 2004. [Consultado 5 de abril de 2010]. Disponible en http:// www.senado.gob.mx/comisiones/LX/grupo_tlcan/content/blanco_datos/ maiz/maiz1/.pdf.

  24. Food and Agriculture Organization of the United Nations. El maíz blanco: un grano alimentario tradicional en los países en desarrollo. [Consultado el 5 de abril de 2010.] ftp://ftp.fao.org/docrep/FAO/006/ w2698s/w2698s00.pdf

  25. Desjardins AE, Plattner RD, Nelson PE. Fumonisin production and other traits of Fusarium moniliforme strains from maize in northeast Mexico. Appl Environ Microbiol 1994;60:1695-1697.

  26. Cortez-Rocha MO, Ramírez-Astudillo WR, Sánchez-Mariñez RI, Rosas-Burgos EC, Wong-Corral FJ, Borboa-Flores J, et al. Fumonisins and fungal species in corn from Sonora, Mexico. Bull Environ Contam Toxicol 2003;70:668-673.

  27. Cortez-Rocha MO, Gil-León ME, Suárez-Jiménez GM, Rosas-Burgos EC, Sánchez-Mariñez RI, Burgos-Hernández A, et al. Occurrence of fumonisin B1 and hydrolyzed fumonisin B1 in Mexican nixtamalized cornmeal. Bull Environ Contam Toxicol 2005;74:73-77.

  28. Sánchez-Rangel D, SanJuan-Badillo A, Plasencia J. Fumonisin production by Fusarium verticillioides strains isolated from maize in Mexico and development of a polymerase chain reaction to detect potential toxigenic strains in grains. J Agric Food Chem 2005;53:8565-8571.

  29. Reyes-Velázquez WP, Isaías-Epinoza VH, Rojo F, Jiménez-Plasencia C, de Lucas Palacios E, Hernández-Góbora J, et al. Ocurrence of fungi and mycotoxins in corn silage, Jalisco State, México. Rev Iberoam Micol 2008;25:182-185.

  30. Dvorak NJ, Riley RT, Harris M, McGregor JA. Fumonisin mycotoxin contamination of corn-based foods consumed by potentially pregnant women in southern California. J Reprod Med 2008;53:672-676.

  31. Robledo M de L, Marin S, Ramos AJ. [Natural contamination with mycotoxins in forage maize and green coffee in Nayarit State (Mexico)]. Rev Iberoam Micol 2001;18:141-4.

  32. US FDA/CFSAN, 2001. Guidance for Industry: Fumonisin levels in human foods and animal feeds; Final Guidance. [Consultado 07/10/09] http://www.fda.gov/Food/GuidanceComplianceRegulatoryInformation/ GuidanceDocument. .

  33. Gutiérrez-Nájera N, Muñoz-Clares RA, Palacios-Bahena S, Ramírez J, Sánchez-Nieto S, Plasencia J, et al. Fumonisin B1, a sphingoid toxin, is a potent inhibitor of the plasma membrane H+-ATPase. Planta 2005;221:589-596.

  34. Del Río-García JC, Moreno-Ramos C, Pinton P, Mendoza-Elvira S, Oswald IP. Evaluation of the cytotoxicity of aflatoxin and fumonisin in swine intestinal cells]. Rev Iberoam Micol 2007;24:136-141.

  35. Rosiles MR, Bautista J, Fuentes VO, Ross F. An outbreak of equine leukoencephalomalacia at Oaxaca, Mexico, associated with fumonisin B1. Zentralbl Veterinarmed A 1998;45:299-302.

  36. Botto LD, Yang Q. 5, 10 Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a huge review. Am J Epidemiol 2000; 151: 862-877.

  37. Guéant-Rodriguez RM, Guéant JL, Debard R, Thirion S, Hong LX, Bronowicki JP, et al. Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations. Am J Clin Nutr 2006;83:701-707.

  38. Mutchinick OM, López MA, Luna L, Waxman J, Babinsky VE.High prevalence of the thermolabile methylenetetrahydrofolate reductase variant in Mexico: a country with a very high prevalence of neural tube defects. Mol Genet Metab 1999;68:461-467.

  39. Blanco-Muñoz J, Lacasaña M, Cavazos RG, Borja-Aburto VH, Galavíz- Hernández C, Garduño CA. Methylenetetrahydrofolate reductase gene polymorphisms and the risk of anencephaly in Mexico. Mol Hum Reprod 2007;13:419-424.

  40. Rodríguez-Guillén M del R, Torres-Sánchez L, Chen J, Galván-Portillo M, Blanco-Muñoz J, Anaya MA, et al. Maternal MTHFR polymorphisms and risk of spontaneous abortion. Salud Publica Mex 2009;51:19-25.

  41. Del Río Garcia C, Torres-Sánchez L, Chen J, Schnaas L, Hernández C, Osorio E, et al. Maternal MTHFR 677C>T genotype and dietary intake of folate and vitamin B(12): their impact on child neurodevelopment. Nutr Neurosci 2009;12:13-20.

  42. Lacasaña-Navarro M, Galván-Portillo M, Chen J, López-Cervantes M, López-Carrillo L. Methylenetetrahydrofolate reductase 677C>T polymorphism and gastric cancer susceptibility in Mexico. Eur J Cancer 2006;42:528-533.




2020     |     www.medigraphic.com