medigraphic.com
Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2010, Number 2

<< Back Next >>

Rev Biomed 2010; 21 (2)

Phosphatidylinositol-4,5-bisphosphate and its complex intracellular actions: focus in ionic channels

Pérez-Burgos A, Alamilla J

Language: Spanish
References: 43
Page: 97-107
PDF size: 197.73 Kb.


ABSTRACT

In recent years, evidence has accumulated about the transcendental role of phosphatidylinositol(4,5) bisphosphate or PI(4,5)P2 and it’s regulation of large groups of ion channels and other equally essential intracellular proteins. This regulation is important due to its role on the release of neurotransmitters, its effects on the firing frequency of cerebral neurons (and other nervous system areas), and even its regulation of the implicated mechanisms in the generation of thermal sensation, arterial pressure regulation and pain sensation, among other processes. Accordingly, if PI(4,5) P2 is capable of modulating the ion channels implicated in these physiologic functions; then, PI(4,5)P2 actions controls multiple cellular processes, and it organizes complex interactions between the cascades of signaling involved in these functions. The aim of this work is the revision of previous significant findings about the growing importance of PI(4,5)P2 in intracellular signal transduction and currently incomplete proposed mechanisms its actions on ion channels. Finally, using current models, it is feasible to conclude that the physical interaction between PI(4,5)P2 and ion channels can be necessary for the opening of many type of ion channels, and the degradation of this phosphoinositide also generally induces an inhibition of the current generated by ion channels.


REFERENCES

  1. Eyster KM. The membrane and lipids as integral participants in signal transduction: lipid signal transduction for the non-lipid biochemist. Adv Physiol Educ 2007; 31:5-16.

  2. Taylor CW. Controlling calcium entry. Cell 2002; 111:767-9.

  3. Wu D, Katz A, Simon MI. Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein. Proc Natl Acad Sci USA 1993; 90:5297-301.

  4. Parker PJ, Murray-Rust J. PKC at a glance. J Cell Sci 2004; 117:131-2.

  5. Caulfield MP. Muscarinic receptors-characterization, coupling and function. Pharmacol Ther 1993; 58:319-79.

  6. McLaughlin S, Murray D. Plasma membrane phosphoinositide organization by protein electrostatics. Nature 2005; 438:605-11.

  7. Wishart MJ, Dixon JE. PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. Trends Cell Biol 2002; 12:579-85.

  8. Huang CL. Complex roles of PIP2 in the regulation of ion channels and transporters. Am J Physiol Renal Physiol 2007; 293:1761-5.

  9. Suh BC, Hille B. Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate. Curr Opin Neurobiol 2005; 15:370-8.

  10. Suh BC, Hille B. PIP2 Is a necessary cofactor for ion channel function: How and Why? Annu Rev Biophys 2008; 37:175-95.

  11. Hilgemann DW, Ball R. Regulation of cardiac Na+, Ca2+ exchange and KATP potassium channels by PIP2. Science 1996; 273:956-9.

  12. Koster JC, Sha Q, Nichols CG. Sulfonylurea and K(+)-channel opener sensitivity of K(ATP) channels. Functional coupling of Kir6.2 and SUR1 subunits. J Gen Physiol 1999; 114:203-13.

  13. Baukrowitz T, Schulte U, Oliver D, Herlitze S, Krauter T, Tucker SJ, et al. PIP2 and PIP as determinants for ATP inhibition of KATP channels. Science 1998; 282:1141-4.

  14. Shyng SL, Nichols CG. Membrane phospholipid control of nucleotide sensitivity of KATP channels. Science 1998; 282:1138-41.

  15. Brown DA, Hughes SA, Marsh SJ, Tinker A. Regulation of M(Kv7.2/7.3) channels in neurons by PIP2 and products of PIP2 hydrolysis: significance for receptor mediated inhibition. J Physiol 2007; 582.3:917-25.

  16. Suh BC, Hille B. Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5- bisphosphate synthesis. Neuron 2002; 35:507-20.

  17. Winks JS, Hughes S, Filippov AK, Tatulian L, Abogadie FC, Brown DA, et al. Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels. J Neurosci 2005; 25:3400-13.

  18. Zhang H, Craciun LC, Mirshani T, Rohacs T, Lopes CMB, Jin T, et al. PIP2 Activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents. Neuron 2003; 37:963-75.

  19. Shen W, Hamilton SE, Nathanson NM, Surmeier DJ. Cholinergic suppression of KCNQ channel currents enhances excitability of striatal medium spiny neurons. J Neurosci 2005; 25:7449-58.

  20. Huang CL, Feng S, Hilgemann DW. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Nature 1998; 391:803-6.

  21. Surmeier DJ, Ding J, Day M, Wang Z, Shen W. D1 and D2 dopamine receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons. Trends Neurosci 2007; 30:228-35.

  22. Shen W, Tian X, Day M, Ulrich S, Tkatch T, Nathanson NM, et al. Cholinergic modulation of Kir2 channels selectively elevates dendritic excitability in striatopallidal neurons. Nat Neurosci 2007; 10:1458-66.

  23. Carr DB, Surmeier DJ. M1 muscarinic receptor modulation of Kir2 channels enhances temporal summation of excitatory synaptic potentials in prefrontal cortex pyramidal neurons. J Neurophysiol 2007; 97:3432-8.

  24. Rittenhouse AR. PIP2 PIP2 hooray for maxi K+. J Gen Physiol 2008; 132:5-8.

  25. Vaithianathan T, Bukiya A, Liu J, Liu P, Asuncion-Chin M, Fan Z, et al. Direct regulation of BK channels by phosphatidylinositol 4,5-biphosphate as a novel signaling pathway. J Gen Physiol 2008; 132:13-28.

  26. Brown DA, Sihra TS. Presynaptic signaling by heterotrimeric G-proteins. Handb Exp Pharmacol 2008; 184:207-60.

  27. Gamper N, Reznikov V, Yamada Y, Yang J, Shapiro MS. Phosphotidylinositol 4,5-bisphosphate signals underlie receptor-specific Gq/11-mediated modulation of N-type Ca2+ channels. J Neurosci 2004; 24:10980-92.

  28. Wu L, Bauer CS, Zhen XG, Xie C, Yang J. Dual regulation of voltage gated calcium channels by PtdIns (4,5) P2. Nature 2002; 419:947-52.

  29. Perez-Burgos A, Prieto GA, Galarraga E, Bargas J. CaV2.1 channels are modulated by muscarinic M1 receptors through phosphoinositide hydrolysis in neostriatal neurons. Neuroscience 2010; 165:293-9.

  30. Catterall WA, Few AP. Calcium channel regulation and presynaptic plasticity. Neuron 2008; 59:882-901.

  31. Perez-Burgos A, Perez-Rosello T, Salgado H, Flores- Barrera E, Prieto G, Figueroa A, et al. Muscarinic M1 modulation of N and L types of calcium channels is mediated by PKC in neostriatal neurons. Neuroscience 2008; 155:1079-97.

  32. Perez-Rosello T, Figueroa A, Salgado H, Vilchis C, Tecuapetla F, Guzman NJ, et al. Cholinergic control of firing pattern and neurotransmission in rat neostriatal projection neurons: role of CaV2.1 and CaV2.2 Ca2+ channels. J Neurophysiol 2005; 93:2507-19.

  33. Salgado H, Tecuapetla F, Perez-Rosello T, Perez- Burgos A, Perez-Garci E, Galarraga E, et al. A reconfiguration of CaV2 Ca2+ channel current and its dopaminergic D2 modulation in developing neostriatal neurons. J Neurophysiol 2005; 94:3771-87.

  34. Le Blanc C, Mironneau C, Barbot C, Henaff M, Bondeva T, Wetzker R, et al. Regulation of vascular L-type Ca2+ channels by phosphatidylinositol 3,4,5- trisphosphate. Circ Res 2004; 95:300-7.

  35. Pochynyuk O, Tong Q, Staruschenko A, Ma HP, Stockand JD. Regulation of the epithelial Na+ channel (ENaC) by phosphatidylinositides. Am J Physiol Renal Physiol 2006; 290:F949-57.

  36. Pochynyuk O, Tong Q, Medina J, Vandewalle A, Staruschenko A, Bugaj V, et al. Molecular Determinants of PI(4,5)P2 and PI(3,4,5)P3 Regulation of the Epithelial Na+ Channel. J Gen Physiol 2007; 130:399-413.

  37. Pochynyuk O, Bugaj V, Stockand JD. Physiologic regulation of the epithelial sodium channel by phosphatidylinositides. Curr Opin Nephrol Hypertens 2008; 17:533-40.

  38. Rohacs T, Thyagarajan B, Lukacs V. Phospholipase C mediated modulation of TRPV1 channels. Mol Neurobiol 2008; 37:153-63.

  39. Chuang HH, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, et al. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5) P2-mediated inhibition. Nature 2001; 411:957-62.

  40. Prescott ED, Julios D. A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Science 2003; 300:1284-8.

  41. Liu B, Zhang C, Qin F. Functional recovery from desensitization of vanilloid receptor TRPV1 requires resynthesis of phosphatidylinositol 4,5-bisphosphate. J Neurosci 2005; 25:4835-43.

  42. Yao J, Qin F. Interaction with phosphoinositides confers adaptation onto the TRPV1 pain receptor. PLoS Biol 2009; 7:e46.

  43. Liu B, Qin F. Functional of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5- bisphosphate. J Neurosci 2005; 25:1674-81.




2020     |     www.medigraphic.com