medigraphic.com
Órgano Oficial de la Asociación Mexicana de Infectología Pediátrica y la SLIPE.

2005, Number 73

<< Back Next >>

Rev Enfer Infec Pediatr 2005; 18.19 (73)

Evaluation of immunoglobulin and complement values in a Mexican newborn healthy population

Soria-Villa R, Reyna-Figueroa J, Lara-Sánchez J, Cérbulo-Vázquez A, Ortiz-Ibarra FJ

Language: Spanish
References: 21
Page: 8-12
PDF size: 44.09 Kb.


ABSTRACT

Objective: To know the normal immunoglobulin (M, G and A) and complement’s component (C3 and C4) concentration at the healthy newborn.
Patients and Methods: Cord blood samples was obtained from newborn’s placentas captured at the Instituto Nacional de Perinatología. By clinical and hematological monitoring, during the first 72 h of intrauterine life, all the newborns were qualified healthy eutrofic. Newborns with age under 28 week of gestation (SDG) or delivery’s products that developed membrane rupture premature over 12 h, or products with infection or congenital malformation were excluded.
Results: One hundred ten newborns were evaluated, 59 males and 51 females. Sixty of them (54.5%) were preterm products and 50 (45.4%) were term products. The IgG average concentration at term newborns (RNT) was 1260 mg7dl, while at preterm newborns (RNPT) was 947 mg/dl. The IgA average concentration at RNT was 8.8 mg7dl, while at RNPT was 1.6 mg/dl. The IgM average concentration at RNT was 18.1 mg7dl, and at RNPT was 13 mg/dl. The C3 average concentration at RNT was 33 mg/dl, while at RNPT 36 mg/dl. The C4 average concentration at RNT was 10.2 mg7dl, while at RNPT 11 mg/dl.
Conclusions: The data suggest that; A) the concentration of certain immunoglobulins and certain complement’s components dose were not different between RNT and RNPT. B) The IgM, IgG e IgA, and C3 y C4´s concentration is higher than the concentration previously reported. And C) It’s probable that the humoral response’s potential at RNT and RNPT could be quite similar.


REFERENCES

  1. Apicella MA, Westerink MAJ, Morse SA, Schneider H, Rice PA, Griffiss JM. Bactericidal antibody response of normal human serum to the lipooligosaccharide of Neisseria gonorrhoeae. J Infect Dis 1997; 153: 520-526.

  2. Lederman HM, Winkelstein JA. X-linked agammaglobulinemia: an analysis of 96 patients. Medicine 1985; 64: 145-156.

  3. Levine B, Hadwick JM, Trapp BD, Crawford TO, Bollinger RC, Griffin DE. Antibody-mediated clearance of alphavirus infection from neurons. Science 1991; 254: 856-860.

  4. Dietzschold B, Kao M, Zheng YM, Chen ZY, maul G, Fu ZF, Rupprecht CE and Koprowski H. Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system. Proc Natl Acad Sci USA 1992; 89: 7252-7256.

  5. Mazanec MB, Kaetzel CS, Lamm ME, Fletcher D, Nedrud JG. Intracellular neutralization of virus by immunoglobulin antibodies. Proc Natl Acad Sci USA 1992; 89: 6901-6905.

  6. Lodmell DL, Esposito JJ, Ewalt LC. Rabies virus anti-nucleoprotein antibody protects against rabies virus challenge in vivo and inhibits rabies virus replication in vitro. J Virol 1993; 67: 6080-6086.

  7. Hodge S, Hodge G, Flower R and Han P. Cord Blood Leukocyte Expression of functionally Significant Molecules Involved in the Regulation of Cellular Immunity. Scand J Immunol 2001; 53: 72-78.

  8. Sautois B, Fillet G and Beguin Y. Comparative cytokine production by in vitro stimulated mononucleated cells from cord blood and adult blood. Exp Hematol 1997; 25(2): 103-108.

  9. Harris DT, Schumacher MJ, Locascio J, Besecon FJ, Olson GB, DeLuca D, Sheker L, Bard J and Moyse EA. Phenotypic and functional immaturity of human cord blood T lymphocytes. Proc Natl Acad Sci USA 1992; 89 (21): 10006-10010.

  10. Urashima M, Hoshi Y, Shishikura A, Kamijo M, Kato Y, Akatsuka J and Maekawa K. Umbilical cord blood as a rich source of immature hematopoietic stem cells. Acta Paediatr Jpn 1994; 36 (6): 649-655.

  11. Takahashi N, Imanishi K, Nishida H and Uchiyama T. Evidence for immunologic immaturity of cord blood T cell. Cord blood T cells are susceptible to tolerance induction to in vitro stimulation with a superantigen. J Immunol 1995; 155 (11): 5213-5219

  12. Vekemans J, Amedei A, Ota MO, D’Elios M, Goetghebuer T, Ismaili 12 J, Newport MJ, Del Prete G, Goldaman M, Mcadam KPWJ and Marchant A. Neonatal bacillus Calmette-Guerin vaccination induces adult-like IFN-( production by CD4+ T lymphocytes. Eur J Immunol 2001; 31: 1531-1535.

  13. Kadowaky N, Antonenko S, Ho S, Rissoan MC, Soumelis V, Porcelli SA, Lanier LL and Liu YJ. Distinct cytokine profiles of neonatal natural killer T cells after expansion with subsets of dendritic cells. J Exp Med 2001; 193 (10): 1221-1226.

  14. Stein KE. Thymus-independent and thymus-dependent responses to polysaccharide antigens. J Infect Dis 1992; 165: S49-S52.

  15. Cooke JV, Holowach J, Atkins JE, Powers JR. Antibody formation in early infancy against diphtheria and tetanus toxoids. J Pediatr 1948; 33: 141-146.

  16. Paton JC, Toogood IR, Cockington RA, Hansman D. Antibody response to pneumococcal vaccine in children aged 5 to 15 years. Am J Dis Child 1986; 140: 135-138.

  17. Oxelius VA and Svenningsen NW. IgG subclass concentrations in preterm neonates. Acta Paedratr Scand 1984; 73: 626-630.

  18. Alford CA Jr, Wu LYF, Blanco A (1974). Developmental humoral immunity and congenital infections in man. In: Neter J, Milgram F (eds) The immune system and infectious diseases. Kerger, Basel. Pp 42-58.

  19. Allansmith M, McClellan BH, Butterwoth M and Maloney JR. The development of immunoglobulin levels in man. The J of Pediat 1968; 72 (2): 276-290.

  20. Yeung CY and Hobbs JR. Serum (G globulin levels in normal premature, post-mature, and “small-for-dates” newborn babies. The Lancet 1968; 1: 1167-1170.

  21. Ballow M, Cates LK, Rowe JC, Goetz C and Desbonnet Ch. Development of the immune system in very low birth weight (less than 1500g) premature infants: Concentrations of plasma immunoglobulins and patterns of infections. Pediatric Res 1986; 20 (9): 899-904.




2020     |     www.medigraphic.com