2009, Number 5
<< Back Next >>
Med Int Mex 2009; 25 (5)
Uso de antibióticos profilácticos en pacientes sometidos a cirugía gastrointestinal hospitalizados en la unidad de terapia intermedia del Hospital Ángeles del Pedregal. Revisión de dos años
López NM, Díaz GEJ, Monteón BIJ
Language: Spanish
References: 20
Page: 337-343
PDF size: 402.05 Kb.
ABSTRACT
Background: The use of prophylactic antibiotics (PAB) in surgery, has demonstrated to reduce the incidence of complications. Nowadays there are international guidelines for the use of PAB, depending on the type of surgery, contamination degree of the wound and bacteria associated. Nevertheless, data shows that the use of PAB is not usually the adequate, even the prolonged use of them haven’t shown better benefit, but does increasing: a) the risk of infection at different sites of the surgery’s wound, b) the antibiotic resistance and c) costs.
Methods: This is a two years retrospective, observational study. We review the charts of 75 patients that underwent gastrointestinal surgery; these patients required management in the Intensive Care Unit of the Hospital Angeles Pedregal. Variables to study were age, sex, days of hospitalization, anesthesic risk, prophylactic antibiotics used and their time of administration.
Results: 57.3% (n=43) were women, and 42.7% (n=32) were men. The average age was 57 years ± 19 with a mean of days of hospitalization of 9 days ± 7. 56% (n=42) of these patients had indication of using PAB, and 32% (n=24) received the prophylaxis recommended time. Two Intrahospital Acquired Pneumonia cases (2.6%) were reported and 2 cases of abdominal sepsis (2.6%).
Conclusions: In less than a half of the cases PAB were administered without specific medical indication. In the most cases studied PAB administration time does not correspond to the data recommended at international guidelines.
REFERENCES
Barie PS, Soumitra R. Surgical site infections. Surg Clin N Am 2005;85:1115-35.
Scottish Intercollegiate Guidelines Network. Antibiotic prophylaxis in Surgery, 2000. www.sign.ac.uk
Servicio de Cirugía General y del Aparato Digestivo. Guía de profilaxis antibiótica. Hospital Universitario Son Dureta 2007;1-28.
Hawn MT, Itani KM, Gray SH, et al. Association of the timely administration of prophylactic antibiotics for major surgical procedures and surgical site infection. J Am Coll Surg 2008;206(5):814-19.
Whitman G, Cowell V, McCullough, et al. Prophylactic antibiotic use: hardwiring of physician behavior, not education, leads to compliance. J Am Coll Surg 2008;207(1):88-94.
Webb A, Flagg R, Fink A. Reducing surgical site infections through a multidisciplinary computerized process for preoperative prophylactic antibiotic administration. Am J Sur 2006;192:663-68.
Lallemand S, Albin C, Huc B, et al. Antibiotic prophylaxis and surgery. Prescription compliance in Franche-Comte with the national reference system. Ann Chir 2001;126(5):463-71.
Malavaud S, Bonnet E, Vigouroux D, et al. Prophylactic antibiotic use in gastro-intestinal surgery: an audit of current practice. J Chir 2008;145(6):579-84.
Zanotto AR, Heineck I, Ferreira MB. Antibiotic prophylaxis in cholecistectomies in a teaching hospital in Brazil. Ann Pharmacother 2006;40(11):2003-7.
Suehiro T, Hirashita T, Araki S, et al. Prolonged antibiotic prophylaxis longer than 24 hours does not decrease surgical site infection after elective gastric and colorectal surgery. Hepatogastroenterology 2008;(86-87):1636-9.
Guirao Garriga X, Badía Pérez JM. Profilaxis antibiótica en cirugía. Guías Clínicas de la Asociación Española de Cirujanos. Madrid: Arán, 2006;pp:121-44
McDonell Norms Group. Antibiotic overuse: the influence of social norms. J Am Coll Surg 2008;207(2):265-75.
Culver DH, Horan TC, et al. Surgical wound infections rates by wound class, operative procedure and patient risk index. National Nosocomial Infections Surveillance System. Am J Med 1991;91:152-7.
James M, Martinez EA. Antibiotics and perioperative infections. Best Pract Res Clin Anaesthesiol 2008;22(3):571-84.
Chang WT, Lee KT, Chuang SC. The impact of prophylactic antibiotics on postoperative infection complication in elective laparoscopic cholecystectomy: a prospective randomized study. Am J Surg 2006;191:721-25.
Nelson RL, Glenny AM, Song F. Cochrane Database Syst Rev. Antimicrobial prophylaxis for colorectal surgery 2009;(1):CD001181.
Targarona EM, Balagué C, Knook MM, Trías M. Laparoscopic surgery and surgical infection. Br J Surg 2000;87:536-44.
Ronald K-W, Patchen D. Current guidelines for antibiotic prophylaxis of surgical wounds. Am Fam Phys 1998;57(11):2731-40.
Bratzler, Houck PM. Antimicrobial prophylaxis for surgery: an advisory statement from the National Surgical Infection Prevention Project. Am J Surg 2005;(189):395- 404.
Slama GT, Amin A, Brunton SA, et al. A clinician’s guide to the appropriate and accurate use of antibiotics: the council for appropriate and rational antibiotic therapy (CARAT) criteria. Am J Med 2005;118(7A):1S-6S.