Carranza MJ, Botello GG, Vega GHE, Maldonado VJA

Language: Spanish
References: 10
Page: 334-337
PDF size: 206.47 Kb.

ABSTRACT

Background: Percentage of patients that reach the goal of cholesterol-LDL with current treatments is low, especially those of high risk as diabetics.
Objective: To determine the effect of 40 mg simvastatin and 10 mg ezetimibe combination on lipid profile, endothelial function, and thickness of the carotid intimate-media in diabetic patients with cholesterol-LDL of 130 mg/dL or higher.
Patients and methods: Sixteen type 2 diabetics were included in an open study but blinded for the laboratory and ultrasound evaluators. Sex, age, weight, height, BMI, waist, BP, cardiovascular risk factors, comorbidities and their treatments, and glycosilated hemoglobin (HbA1c) were registered. Values of TGO, TGP, CPK, lipid profile, thickness of intimate-media carotid, and endothelial function were measured before and eight weeks after the treatment.
Results:Total cholesterol changed from 232.25 ± 24.2 to 126 ± 34.9 (-45.68%), cholesterol-LDL from 144.3 ± 12.8 to 52.5 ± 29.02 (- 63.88%), triglycerides 211.06 ± 90.3 to 162.3 ± 78.03 (-23.22%), and cholesterol-HDL from 45.7 ± 12.01 a 40.4 ± 10.612 mg/dL (-9.09%), all with p ‹ 0.05. There were no changes in TGO, TGP, neither CPK. Endothelium-dependent vasodilatation increased from 14.2 ± 10.2 to 26.2 ± 33.9%. Thickness of intimate-media carotid decreased from 0.91 ± 0.29 to 0.82 ± 0.22 mm. Thirteen patients reached the goal of less than 70 mg/dL of cholesterol-LDL and only one didn’t reach 100 mg/dL.
Conclusions: Simvastatin combined with ezetimibe is a sure treatment, effective to reach the goal of the cholesterol-LDL; it decreases atherosclerosis and improves endothelial function in diabetic patients.

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