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2009, Number 4

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Rev Inst Nal Enf Resp Mex 2009; 22 (4)

Erythrocyte dysfunction in tissue hypoxia in patients with COPD and its relationship with oxidative stress

Torres-Ramos YD, Montoya-Estrada A, Hicks GJJ

Language: Spanish
References: 43
Page: 356-365
PDF size: 526.54 Kb.


ABSTRACT

The body needs oxygen in order to cells exert their respiratory function and generate ATP, and thus insufficient oxygenation provokes tissue hypoxia and functional cell abnormalities. This condition occurs in certain respiratory diseases such as COPD. Patients with COPD have an increased production of reactive oxygen- or nitrogen- species originated in different tissues. The generation of reactive molecules is concomitant with a decreased efficiency of antioxidant systems, resulting in a metabolic state that favors an imbalance of redox homeostasis called oxidative stress. As a result of this stress, structural and functional changes occur in nearly all tissues. This includes erythrocytes, in which a diminished ability to transport and diffuse oxygen to tissues exist because of a decreased oxygen-carrying ability of hemoglobin due to the oxidation of iron to the ferric state (methemoglobin). On the other hand, erythrocytes need to maintain the integrity of its membrane, supported by the catalytic function of proteins that make up the so-called band 3, constituted by the main aggregate of proteins embedded in its membrane and that, due to its structure, is also likely to be affected by the oxidative stress in COPD.


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