Yáñez-Jácome JC, Vergara-López A, Joya-Galeana J, Juárez-Rico MS, Martínez-Elizondo G

Language: Spanish
References: 9
Page: 148-152
PDF size: 116.84 Kb.

ABSTRACT

Background: The recent rise in the prevalence of primary hyperaldosteronism (PHA) is due in part to an increment in the utilization of aldosterone and renin measurements in the evaluation of patients with hypertension. Yet, the assays used in such determinations can be highly variable and need standardization and validation. Objective: To measure plasma aldosterone and plasma renin activity in healthy individuals in order to establish the aldosterone/renin ratio (ARR) that best discriminates normal subjects from those with a high probability of having PHA. Materials and methods: Plasma aldosterone and plasma renin activity were measured in a group of healthy individuals and the ARR was thus calculated, distributing the results by percentiles. Results: Fifty two healthy subjects with a mean age of 34 years (range 18-63) were studied. The ARR ranged between 1.41 to 24.13, with a mean of 9.47. Only those subjects that lied within the 97^th percentile reached ARR values higher than 20. Conclusions: An ARR above 20 efficiently discriminates normal subjects from those hypertensive patients with a high probability of having PHA.

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