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2003, Number 3

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Rev Inst Nal Enf Resp Mex 2003; 16 (3)

Apoptosis as immunoregulation mechanism in physiologic and pathologic conditions associated to lung.

Barrera RLM, Gómez AF, Vázquez CL, Navarro MC, Mendoza PF

Language: Spanish
References: 32
Page: 173-180
PDF size: 179.59 Kb.


ABSTRACT

All multicellular organisms have mechanisms to kill their own cells, and use physiological cell death for defense, development, homeostasis and aging. Apoptosis is a morphologically recognizable form of cell death, implemented by a mechanism that has been conserved throughout evolution from nematodes to man. Abnormalities in cell death control can contribute to a variety of diseases, including cancer, autoimmunity and degenerative disorders. Apoptosis of lung cells occurs during lung infections and may be either a host defense mechanism or reflect the pathogenesis of the infection. In the first part of this review, the physiology of apoptotic pathways is discussed. This is followed by an overview of apoptotic mechanisms in selected lung pathologies.


REFERENCES

  1. Lockshin RA, Osborne B, Zakeri Z. Cell death in the third millenium. Cell Death Diff 2000;7:2-7.

  2. Horvitz H, Greenwald IS, Stenberg PW. The lin-12 locus specifies cell fates in Caenorhabditis elegans. Cell 1983;34:435-444.

  3. Raff M. Cell suicide for beginners. Nature 1998;396:119-122.

  4. Vaux DA. The molecular biology of apoptosis. Proc Natl Acad Sci USA 1996;93:2239-2244.

  5. Konopleva M, Shourong Z, Zhong X, Segall H, Younes A, Claxton D, et al. Apoptosis. Molecules and mechanisms. Drug resistance in leukemia and Lymphoma III. 1999:217-236.

  6. Strasser A, O’Connor L, Dixit V. Apoptosis signaling. Ann Rev Biochem 2000;69:217-245.

  7. Krammer PH. CD95’s deadly mission in the immune system. Nature 2000;407:789-795.

  8. Meier P, Finch A, Evan G. Apoptosis in development. Nature 2000;407:796-801.

  9. Wu YC, Horvitz HR. The C elegans cell corpse engulfment gene ced-7 encodes a protein similar to human ABC transporters. Cell 1998;93:951-960.

  10. Savill J, Dransfield I, Gregory C, Haslett C. A Blast from the past: Clearance of apoptotic cells regulates immune responses. Nat Rev Immunol 2002;2:965-975.

  11. Vaughan ATM, Betti CJ, Villalobos MJ. Surviving apoptosis. Apoptosis 2002;7:173-177.

  12. Oka K. Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells. Proc Natl Acad Sci USA 1998;95:9535-9540.

  13. Rubartelli A, Foggi A, Zoochi M. The selective engulfment of apoptotic bodies by dentritic cells is mediated by alfa 4 beta 3 integrin and requires intracellular and extracelular calcium. Eur J Immunol 1997;27:1893-1900.

  14. Menfredi AA, Lannacone M, D’Auria F, Rovere-Querini P. The disposal of dying cells in living tissues. Apoptosis 2002;7:153-161.

  15. Thompson CG. Apoptosis in the pathogenesis and treatment of disease. Science 1995;267:1456-1462.

  16. Naik P, Karrim J. The rise and fall of apoptosis during multistage tumorigenesis: down modulation contributes to tumor progression from angiogenic progenitors. Genes Dev 1996;10:2105-2116.

  17. Stambolic V, Maak TW. Modulation of cellular apoptotic potential: Contribution to oncogenesis. Oncogene 1999; 18:6094-6103.

  18. Gores SHKaGJ. Apoptosis in cancer: Cause and cure. BioEssays 2000;22:1007-1017.

  19. Yankner JB. Apoptosis in the nervous system. Nature 2000;407:802-809.

  20. Donald F. From bench to clinic with apoptosis-based therapeutic agents. Nature 2000;407:810-816.

  21. Mehrdad B, Robertson KE, Martin WJ. Role of apoptosis in host defense and pathogenesis of disease. Chest 2000; 117:1771-1777.

  22. Hinshaw V, Olsen CW, Dybdahi-Sissoko N. Apoptosis: a mechanism of cell killing by influenza A and B viruses. J Virol 1994;68-71.

  23. Tanaka MY, Maeyama N, Hagimoto K, Kuwano H. Resistance to Fas-mediated apoptosis in human lung fibroblast. Eur Respir J 2002;20:359-368.

  24. Stridh H, Planck D, Gigliotti A, Eklund J, Grunewald D. Apoptosis resistant bronchoalveolar lavage (BAL) fluid lymphocytes in sarcoidosis. Thorax 2002;57:897-901.

  25. Uhal B, Joshi I, Mundle S, Raza S, Pardo A, Selman M. Fibroblast isolated after fibrotic lung induce apoptosis of alveolar epithelial cells in vitro. Am J Physiol 1995;269:L819-L828.

  26. Uhal B, Iravati J, Ramos C, Pardo A, Selman M. Alveolar epithelial cell death adjacent to underlying myofibroblast in advanced fibrotic human lung. Am J Physiol 1988;275: L1192-L1199.

  27. Agostini CP, Semenzato G. Cell apoptosis and granulomatous lung disease. Curr Opin Pulm Med 1998;4:261-266.

  28. Agostini C, Adami F, Semenzato G. New insights into the sarcoid granuloma. Curr Opin Rheumatol 2000;12:71-76.

  29. Cree I, Nurbhai S, Milne G. Cell death in granuloma: the role of apoptosis. J Clin Pathol 1987;40:1314-1319.

  30. Agostini C, Zambello R, Sancetta R. Expresión of tumor necrosing factor-receptor superfamily members by lung T-lymphocytes in interstitial lung disease. Am J Respir Crit Care Med 1996;153:1359-1367.

  31. Kunitake R, Kuwano H, Miyazaki N. Apoptosis in the course of granulomatous inflammation in pulmonary sarcoidosis. Eur Respir J 1999;13:1329-1337.

  32. Dai H, Guzman J, Costabel U. Increased expression of apoptosis signaling receptors by alveolar macrophages in sarcoidosis. Eur Respir J 1999;13:1451-1454




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