2003, Number 3
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Rev Inst Nal Enf Resp Mex 2003; 16 (3)
AIDS in children: Ten-year experience at the National Institute of Respiratory Diseases.
José Gil Cota Montoya, Teresita de Jesús Gutiérrez García, María Silvia Lule Morales, Alejandro Alejandre García
Language: Spanish
References: 14
Page: 145-149
PDF size: 66.90 Kb.
ABSTRACT
The first report of AIDS in children in the US was in 1982 and in Mexico it was diagnosed at the Infantile Hospital of Mexico in 1986. The situation of AIDS in children is particularly important, since children of infected mothers frequently end up as orphans.
Material and methods: The clinical history of 13 children diagnosed with AIDS/HIV in a period of 10 years (January 1993 – July 2003) at the Pediatric Pneumology Service of the National Institute for Respiratory Diseases were reviewed, with attention to X-ray results and most frequently isolated microorganisms, lymphocytic subpopulation and mechanism of acquisition of the disease.
Results: A total of 13 pediatric patients with AIDS diagnosis were found; the main mechanism of transmission of the disease was vertical. Age of diagnosis had prevalence in the younger than two-year olds. The lymphocytic subpopulation was determined in 9 out of 13 patients and in 7 CD4+ was reduced. The most frequently isolated microorganisms was Mycobacterium tuberculosis in 6 cases, followed by cytomegalovirus. The most common X-ray pattern observed at the time of diagnosis was interstitial image.
Conclusions: The microorganisms that affect the lung most frequently in pediatric AIDS infection were established and found to be different from those that affect adults under the same conditions, since in these the most frequent microorganism is Pneumocystis carinii. The time of diagnosis was found to be much longer than in adults.
REFERENCES
Lindegren ML, Steinberg S, Byers RH. Epidemiology of HIV/AIDS in children. Pediatr Clin North Am 2000;47:1-17.
Fowler MG, Simonds RJ, Roongpisuthipong A. Update on perinatal HIV transmission. Pediatr Clin North Am 2000;47:21-38.
Church JA, Hart I. Transfusion-associated acquired immune deficiency syndrome in infants. J Pediatri 1984;105:731-737.
Parks W. Epidemiología del virus de la inmunodeficiencia humana. En: Nelson, editor. Tratado de pediatría médica. San Francisco California: Manual Moderno, 1993:1154-1158.
Calvelli TA, Rubinstein A. Pediatric HIV infection. A review. Immunodefic Rev 1990;2:83.
Pizzo PA. Pediatric AIDS: Problems within problems. J Infect Dis 1990;161: 316-325.
Inselman LS. Pediatric human immunodeficiency virus infection. In: Hilman, editor. Pediatric respiratory diseases. Louisiana: Saunders, 1993:198-201.
López LP, Levy FA. Complicaciones pulmonares asociadas a la infección por VIH. En: Reyes, editor. Neumología pediátrica. Bogotá, Colombia: Panamericana, 1998:533-546.
Bernstein LJ, Ochs HD, Wedgwood RJ, Rubinstein A. Defective humoral immunity in pediatric acquired immune deficiency syndrome. J Pediatr 1985;107:352-356.
William E. Virus de la inmunodeficiencia humana. En: Hathaway, editor. Diagnóstico y tratamiento pediátrico. Colorado, EU: Manual Moderno, 1995:1042.
Calpe JL, Chiner E, Marin, Martínez C, López MM, Sánchez E. Tuberculosis notification from 1987 to 1999 for the public health area of de community of Valencia (Spain). Arch Bronconeumol 2001;37:417-423.
Raviglioni MC, O’ Brien RJ. Tuberculosis. En: Fausi AS, Braun WE, Isselbhacher KJ, Wilson JD, Martín JB, Casper DL, et al, editors. Harrison. Principios de medicina interna. 14ª ed. Madrid: Mc GrawHill-Interamericana, 1998: 1149-1161.
Decker CF, Lazarus. Tuberculosis and HIV infection how to safety treat both disorders concurrently. Postgrad Med 2000;108:57-68.
Abrams EJ. Opportunistic infections and other clinical manifestation of VIH disease in children. Pediatr Clin North Am 2000;47:79-108.