medigraphic.com
A partir del año 2010, la Revista Oficial del INER cambió a NCT (Neumología y Cirugía de Tórax)

 Ver actualización

2009, Number 3

<< Back Next >>

Rev Inst Nal Enf Resp Mex 2009; 22 (3)

Galectin-1: down-regulator of the inflammatory immune response and possible therapeutic agent

Ortiz-Quintero B

Language: Spanish
References: 58
Page: 206-216
PDF size: 198.84 Kb.


ABSTRACT

The inflammatory response is an essential, self-limited and highly regulated process for pathogens elimination. A defective regulation of the inflammatory response leads to the development of pathological conditions such as autoimmunity and chronic inflammation, while a lack of an inflammatory response allows the progression of microbial infections or tumor development. Galectin-1 is an endogenous protein of the lectins family that regulates immune homeostasis through its specific binding to glycosylated structures on the cell surface of immature and activated T cells, resulting in induction of cell death by apoptosis. Recent evidences indicate that treatment with galectin-1 skews the balance from a TH1- toward a TH2-polarized immune response in different experimental models of autoimmunity, chronic inflammation and cancer. These findings draw attention to the anti-inflammatory function of galectin-1 and its potential use as an anti-inflammatory agent for the treatment of autoimmune diseases, graft rejection, chronic inflammation and recurrent fetal loss. This review summarizes the current knowledge about galectin-1 expression and function on T cell homeostasis, and its role in experimental models of inflammation-mediated disorders.


REFERENCES

  1. Sprent J, Tough DF. T cell death and memory. Science 2001;293:245-248.

  2. Rathmell JC, Thompson CB. Pathways of apoptosis in lymphocyte development, homeostasis, and disease. Cell 2002;109 Suppl:S97-S107.

  3. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995;267:1456-1462.

  4. Tsujimoto Y. Cell death regulation by the Bcl-2 protein family in the mitochondria. J Cell Physiol 2003;195: 158-167.

  5. Ware CF, VanArsdale S, VanArsdale TL. Apoptosis mediated by the TNF-related cytokine and receptor families. J Cell Biochem 1996;60:47-55.

  6. Hengartner MO. The biochemistry of apoptosis. Nature 2000;407:770-776.

  7. Leffler H, Carlsson S, Hedlund M, Qian Y, Poirier F. Introduction to galectins. Glycoconj J 2004;19:433-440.

  8. Cooper DN. Galectinomics: finding themes in complexity. Biochim Biophys Acta 2002;1572:209-231.

  9. Dunphy JL, Barcham GJ, Bischof RJ, Young AR, Nash A, Meeusen EN. Isolation and characterization of a novel eosinophil-specific galectin released into the lungs in response to allergen challenge. J Biol Chem 2002;277:14916-14924.

  10. Gray CA, Adelson DL, Bazer FW, Burghardt RC, Meeusen EN, Spencer TE. Discovery and characterization of an epithelial-specific galectin in the endometrium that forms crystals in the trophectoderm. Proc Natl Acad Sci U S A 2004;101:7982-7987.

  11. Hirabayashi J, Kasai K. The family of metazoan metal-independent ß-galactoside-binding lectins: structure, function and molecular evolution. Glycobiology 1993;3:297-304.

  12. Perillo NL, Pace KE, Seilhamer JJ, Baum LG. Apoptosis of T cells mediated by galectin-1. Nature 1995;378:736-739.

  13. Perillo NL, Uittenbogaart CH, Nguyen JT, Baum LG. Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes. J Exp Med 1997;185:1851-1858.

  14. Hahn HP, Pang M, He J, et ál. Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death. Cell Death Differ 2004;11:1277-1286.

  15. Garín MI, Chu CC, Golshayan D, Cernuda-Morollón E, Wait R, Lechler RI. Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. Blood 2007;109:2058-2065.

  16. Santucci L, Fiorucci S, Rubinstein N, et ál. Galectin-1 suppresses experimental colitis in mice. Gastroenterology 2003;124:1381-1394.

  17. Toscano MA, Bianco GA, Ilarregui JM, et ál. Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death. Nat Immunol 2007;8:825-834.

  18. Rubinstein N, Alvarez M, Zwirner NW, et ál. Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege. Cancer Cell 2004;5:241-251.

  19. Cho M, Cummings RD. Galectin-1, a beta-galactoside-binding lectin in Chinese hamster ovary cells. I. Physical and chemical characterization. J Biol Chem 1995; 270:5198-5206.

  20. López-Lucendo MF, Solís D, André S, et ál. Growth-regulatory human galectin-1: crystallographic characterization of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding. J Mol Biol 2004;343:957-970.

  21. Pace KE, Lee C, Stewart PL, Baum LG. Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1. J Immunol 1999;163:3801-3811.

  22. Pace KE, Hahn HP, Pang M, Nguyen JT, Baum LG. CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death. J Immunol 2000;165:2331-2334.

  23. Baum LG, Pang M, Perillo NL, et ál. Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells. J Exp Med 1995;181:877-887.

  24. Galvan M, Tsuboi S, Fukuda M, Baum LG. Expression of a specific glycosyltransferase enzyme regulates T cell death mediated by galectin-1. J Biol Chem 2000;275: 16730-16737.

  25. Grabie N, Delfs MW, Lim YC, Westrich JR, Luscinskas FW, Lichtman AH. Beta-galactoside alpha2,3-sialyltransferase-I gene expression during Th2 but not Th1 differentiation: implications for core2-glycan formation on cell surface proteins. Eur J Immunol 2002;32: 2766-2772.

  26. Blaser C, Kaufmann M, Müller C, et ál. B-galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells. Eur J Immunol 1998;28:2311-2319.

  27. Zuñiga EI, Rabinovich GA, Iglesias MM, Gruppi A. Regulated expression of galectin-1 during B-cell activation and implications for T-cell apoptosis. J Leukoc Biol 2001;70:73-79.

  28. Rabinovich GA, Iglesias MM, Modesti NM, et ál. Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: biochemical and functional characterization. J Immunol 1998;160:4831-4840.

  29. Kopcow HD, Rosetti F, Leung Y, Allan DS, Kutok JL, Strominger JL. T cell apoptosis at the maternal-fetal interface in early human pregnancy, involvement of galectin-1. Proc Natl Acad Sci U S A 2008;105:18472-18477.

  30. Dettin L, Rubinstein N, Aoki A, Rabinovich GA, Maldonado CA. Regulated expression and ultrastructural localization of galectin-1, a proapoptotic b-galactoside-binding lectin,during spermatogenesis in rat testis. Biol Reprod 2003;68:51-59.

  31. Ishida K, Panjwani N, Cao Z, Streilein JW. Participation of pigment epithelium in ocular immune privilege. 3. Epithelia cultured from iris, ciliary body, and retina suppress T-cell activation by partially non-overlapping mechanisms. Ocul Immunol Inflamm 2003;11:91-105.

  32. Priatel JJ, Chui D, Hiraoka N, et ál. The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis. Immunity 2000;12:273-283.

  33. Baum LG, Derbin K, Perillo NL, Wu T, Pang M, Uittenbogaart C. Characterization of terminal sialic acid linkages on human thymocytes. Correlation between lectin-binding phenotype and sialyltransferase expression. J Biol Chem 1996;271:10793-10799.

  34. Piller F, Piller V, Fox RI, Fukuda M. Human T-lymphocyte activation is associated with changes in O-glycan biosynthesis. J Biol Chem 1988;263:15146-15150.

  35. Rabinovich GA, Alonso CR, Sotomayor CE, Durand S, Bocco JL, Riera CM. Molecular mechanisms implicated in galectin-1-induced apoptosis: activation of the AP-1 transcription factor and downregulation of Bcl-2. Cell Death Differ 2000;7:747-753.

  36. Ion G, Fajka-Boja R, Kovács F, et ál. Acid sphingomyelinase-mediated release of ceramide is essential to trigger the mitochondrial pathway of apoptosis by galectin-1. Cell Signal 2006;18:1887-1896.

  37. Hahn HP, Pang M, He J, et ál. Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death. Cell Death Differ 2004;11:1277-1286.

  38. Matarrese P, Tinari A, Mormone E, et ál. Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission. J Biol Chem 2005;280: 6969-6985.

  39. Brandt B, Büchse T, Abou-Eladab EF, et ál. Galectin-1 induced activation of the apoptotic death-receptor pathway in human Jurkat T lymphocytes. Histochem Cell Biol 2008;129:599-609.

  40. Stowell SR, Qian Y, Karmakar S, et ál. Differential roles of galectin-1 and galectin-3 in regulating leukocyte viability and cytokine secretion. J Immunol 2008;180: 3091-3102.

  41. Motran CC, Molinder KM, Liu SD, Poirier F, Miceli MC. Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function. Eur J Immunol 2008;38:3015-3027.

  42. Liu SD, Whiting CC, Tomassian T, et ál. Endogenous galectin-1 enforces class I-restricted TCR functional fate decisions in thymocytes. Blood 2008;112:120-130.

  43. Chung CD, Patel VP, Moran M, Lewis LA, Miceli MC. Galectin-1 induces partial TCR z-chain phosphorylation and antagonizes processive TCR signal transduction. J Immunol 2000;165:3722-3729.

  44. Rabinovich GA, Ariel A, Hershkoviz R, Hirabayashi J, Kasai KI, Lider O. Specific inhibition of T-cell adhesion to extracellular matrix and proinflammatory cytokine secretion by human recombinant galectin-1. Immunology 1999;97:100-106.

  45. He J, Baum LG. Endothelial cell expression of galectin-1 induced by prostate cancer cells inhibits T-cell transendothelial migration. Lab Invest 2006;86:578-590.

  46. Norling LV, Sampaio AL, Cooper D, Perretti M. Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking. FASEB J 2008;22:682-690.

  47. Offner H, Celnik B, Bringman TS, Casentini-Borocz D, Nedwin GE, Vandenbark AA. Recombinant human b-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis. J Neuroimmunol 1990;28:177-184.

  48. Rabinovich GA, Daly G, Dreja H, et ál. Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis. J Exp Med 1999;190:385-398.

  49. Santucci L, Fiorucci S, Cammilleri F, Servillo G, Federici B, Morelli A. Galectin-1 exerts immunomodulatory and protective effects on concanavalin A-induced hepatitis in mice. Hepatology 2000;31:399-406.

  50. Santucci L, Fiorucci S, Rubinstein N, et ál. Galectin-1 suppresses experimental colitis in mice. Gastroenterology 2003;124:1381-1394.

  51. Baum LG, Blackall DP, Arias Magallano S, et ál. Amelioration of graft versus host disease by galectin-1. Clin Immunol 2003;109:295-307.

  52. Toscano MA, Commodaro AG, Llarregui JM, et ál. Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses. J Immunol 2006;176: 6323-6332.

  53. Perone MJ, Bertena S, Tawadrous ZS, et ál. Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice. J Immunol 2006;177: 5278-5289.

  54. Perone MJ, Bertera S, Shufesky WJ, et ál. Suppression of autoimmune diabetes by soluble galectin-1. J Immunol 2009;182:2641-2653.

  55. Tsuchiyama Y, Wada J, Zhang H, et ál. Efficacy of galectins in the amelioration of nephrotoxic serum nephritis in Wistar Kyoto rats. Kidney Int 2000;58:1941-1952.

  56. Harjacek M, Diaz-Cano S, De Miguel M, Wolfe H, Maldonado CA, Rabinovich GA. Expression of galectins-1 and -3 correlates with defective mononuclear cell apoptosis in patients with juvenile idiopathic arthritis. J Rheumatol 2001;28:1914-1922.

  57. Romero MD, Muiño JC, Bianco GA, et ál. Circulating anti-galectin-1 antibodies are associated with the severity of ocular disease in autoimmune and infectious uveitis. Invest Ophthalmol Vis Sci 2006;47:1550-1556.

  58. Giordanengo L, Gea S, Barbieri G, Rabinovich GA. Anti-galectin-1 autoantibodies in human Trypanosoma cruzi infection: differential expression of this b-galactoside-binding protein in cardiac Chagas’ disease. Clin Exp Immunol 2001;124:266-273.




2020     |     www.medigraphic.com