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2009, Number 2

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Rev Inst Nal Enf Resp Mex 2009; 22 (2)

Idiopathic pulmonary fibrosis and cigarette smoking

Checa CMA

Language: Spanish
References: 29
Page: 117-123
PDF size: 91.92 Kb.


ABSTRACT

Idiopathic pulmonary fibrosis is a chronic and progressive lung disorder of unknown etiology for which an effective treatment is still lacking. Up to date pathogenic mechanisms involved in its development are unknown, but several studies suggest that some environmental factors may play a causative role in this diseases. Thus, first association studies performed at the beginning of the 1990 decade showed that smoking, among other conditions, is an important risk factor. Interestingly, a recent meta-analysis that evaluated different exposures corroborated that tobacco habit was a major risk factor. However, mechanisms involved in this association are unknown, since up to now few experimental models to study the influence of tobacco smoke in the origin of pulmonary fibrosis have been developed. One of these models demonstrated that guinea pigs exposed to cigarette smoke display an increase fibrotic response induced by bleomycin. On the other hand, with the aim to understand this response, experimental models have shown that elastolytic emphysema precedes fibrosis, and that neutrophil elastase might represent a common factor linking emphysema and fibrosis, acting as a regulator in the generation of soluble cytokines such as TGF-b.


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