2000, Number 1
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Alerg Asma Inmunol Pediatr 2000; 9 (1)
Clinical profile in patients with atopic dermatitis
Almendarez FC, Jiménez CI, Orozco MS
Language: Spanish
References: 22
Page: 6-15
PDF size: 682.81 Kb.
ABSTRACT
Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin condition; is consider like allergic disease and produce a substantial pediatric morbidity and individual dysfunction, making its mechanisms and appropriate target for preventive strategies. Knowing the clinical and epidemiological characteristics of the patients with atopic dermatitis are important in order to recognize a clinical profile who allow to the pediatrician and allergist to take preventive measures in our population.
Methods: This is a retrospective, descriptive cohort study. We revised all clinical records of the patients with criteria of atopic dermatitis since January 1989 to December 1999, in the Allergy Department of the National Institute of Pediatrics in Mexico City. The major objective of this study was identifying the clinical and epidemiological characteristics to define the clinical profile of the patient with atopic dermatitis. The variables studied were: gender, age, family history of allergy, weight and high percentiles, time of breastfeeding, major and minor criteria, anatomic site of the eczema, medical and allergic diagnosis associated with atopic dermatitis sensitization to allergens, treatment and evolution.
Results: We include 76 clinical records of patients with criteria of atopic dermatitis. The average of age was seven years (range 0.8-14 years) 65.8% (50/76) of the patients were male and 72% (55/76) of the patients were from Mexico city and 28% (21/76) from other states. 59% have weight and high in 50/50 percentile diagnosis (Tubular renal acidosis, Hypothyroidism, Immunodeficiency). The more frequent localization of the eczema were flexural areas, 83% (63/76) have prick skin test positive and five were minor to 1 year old. The food allergy was associated in 17% of the patients and 74% (47/63) were sensitized to Dpt, Df. The more frequent exacerbation factors were skin infections (48%) dust (23%) food (21%) sweat (8%). 38% of the patients show asthma and allergic rhinitis associated with atopic dermatitis. 98.7% had a good clinical evolution 87% of the patient with skin prick test use immunotherapy without relapses.
Discussion: The clinical profile of the patients attend in the National Institute of Pediatrics were frequently male gender, between 6 to 9 years with weight ant high in the 50/50 percentile, positive family history of allergy, and received less than 3 months of breastfeeding enhancing the risk of sensitization to aeroallergens and are associated with asthma and allergic rhinitis.
REFERENCES
Zeiguer RS, Heller S. The development and prediction of atopy in high-risk childrens: follow-up at age seven years in prospective randomized study of combined maternal and infant food allergen avoidence. J Allergy Clin Immunol 1995; 95: 1179-90.
Woodmansee D, Christiansen S. Atopic dermatitis. Pediatric Annals 1998; 27: 11.
Solomon R. Prevention of allergic disorders. Pediatr Rev 1994; 15: 301-9.
Hide DW. Early intervention for the prevention of atopic dermatitis. Pediatr Allergy Immunol 1997; 87: 4-10.
Cantani A, Gagliest D. Prediction and prevention of atopic disease in at risk children. Eur Rev Med Pharmacol Sci 1998; 2: 115-25.
Resano A, Crespo E, Fernanadez BM, Sanz ML, Oehling A. Atopic dermatitis and food allergy. J Investig Clin Immunol 1998; 8: 271-6.
Beltrani V. Atopic dermatitis-Allergic or non- Allergic syllabus Allergyc Asthma & Immunology. ACAAI. Philadelphia 1998; 6-11.
Schafer T, Heinrich J, Wjst M, Adam H, Ring J, Wichmann HE. Association between severity of atopic eczema and degree of sensitization to aeroallergens in schoolchildren. J Allergy Clin Immunol 1999; 104: 1280-4.
Kuling M, Bergmann R, Niggemann B, Burrow G, Wahn U. Prediction of sensitization to inhalant allergens in childhood: evaluating family history, atopic dermatitis and sensitization to food allergens. The MAS study group. multycentre allergy study. Clin Exp Allergy 1998; 28: 1397-403.
Sutthispisal N, Mcfadden JP, Cronin E. Sensitization in atopic and non atopic Hairdressers with hand eczema. Contact Dermatitis 1993; 29: 206-9.
Gullet G, Guillet MH. Natural history of sensitizations in atopic dermatitis. A 3-year follow up in 250 children: food allergy and high risk of respiratory symptoms. Arch Dermatol 1992; l28: 187-92.
Etac (Early Treatment of the Atopic Child) a multicentre European Study. Determinants of total and specific IgE in infants with atopic dermatitis. J Allergy Clin Immunol 1998; 101(1Pt 1): 84-9.
Gutgesell C, Seubert A, Jughans V, Neumann C., Inverse correlation of domestic exposure to Dermatophagoides pteronyssinus antigen patch test reactivity in patients with atopic Dermatitis. Clin Exp Allergy 1998; 28: 965-70.
Nickel R, Kulling M, Fodter J, Bergmann R, Bauer CP, Lau S, Guggenmoos-Holzmann I, Wahn U. Sensitization to hen’s egg at age of twelve is predictive for allergic sensitization to common indoor and aoutdoor allergens at age of three years. Acta Paediatr 1997; 86: 1188-94.
Oehling A, Fernandez M, Cordoba H, Sanz ML. Skin manifestations and immunological parameters in childhood food Allergy. J Investig Allergol Clin Immunol 1997; 7: 98-102.
Bunikowski R, Mielke M, Skarabis H, Herz U, Bergmann RL, Wahn U. Prevalence and role of serum IgE antibodies to Staphylococcus aureus-Derived superantigens sea and seb in children with atopic dermatitis. J Allergy Clin Immunol 1999; 103: 119-24.
Niels M, Dahl R, Soren P. Essential allergy Clackwell Science. Second Edition Hamilton Canada 1996.
Wüthrich B. Clinical aspects, Epidemiology and prognosis of atopic dermatitis. Annals of Allergy, Asthma, & Immunology 1999, 83.
Schuftz LF. The epidemiology of atopic dermatitis. In Burr ML ed. Epidemiology of clinical allergy. Basel: Karger 1993; 31: 9-28.
Isolauri E, Tahvanainen A, Peltola T, Arvola T. Breast-feeding of allergic infants. J Pediatr 1999; 134: 27-31.
Vandenplas Y. Pathogenesis of food allergy in infants. Curr Opin Pediatr 1993; 5: 567-72.
Scalabrin DM, Bavbeck S, Perzanowoski MS, Wilson BB, Platts-Mills TA. Use of specific IgE in assessing the relevance of fungal and dust mite allergens to atopic dermatitis: a comparison with asthmatic and non asthmatic control subjects. J Allergy Clin Immunol 1999; 104: 1273-9.