Villegas-Gómez RM, Sánchez-Zárate DA, Mejía-Terrazas GE

Language: Spanish
References: 12
Page: 223-226
PDF size: 71.95 Kb.

ABSTRACT

Introduction: Most postoperative patients do not receive adequate relief. In this area is where analgesic combinations may have advantages. Therefore, we decided to evaluate what the best dose of the combination of tramadol + ketorolac to control postoperative pain secondary to open cholecystectomy. Material and methods: 258 patients randomized into 3 groups were studied. Group 1 received 50 mg tramadol plus 20 mg ketorolac, Group 2 received 100 mg and 40 mg respectively, Group 3 placebo. Group 1 received 50 mg tramadol plus 20 mg ketorolac; Group 2 received 100 mg tramadol plus 40 mg ketorolac, and Group 3 received placebo. Intensity and pain quality were assessed using a visual analogue scale and the simplified version of the McGill questionnaire, respectively, every 4 hours for 24 hours. The adverse effects also were assessed. Statistical analysis, mean, standard deviation, chi-square test and student’s t-test. Results: Pain intensity in the Group 1 was 4.62 ± 0.67, Group 2 was 2.97 ± 0.91, and Group 3 was 8.36 ± 0.80, P value ≤ 0.0001. The qualities of the pain were Group 1: 5.08 ± 1.44, Group 2: 4.17 ± 1.13, and Group 3: 8.14 ± 0.83., P ≤ 0.001. Pain-free time was Group 1: 15.20 ± 3.29 hrs; Group 2: 20.00 ± 4.38, and Group 3: 4.70 ± 1.40 hours, P ≤ 0.0003. Side effects were Group 1: vomiting (9.3%), nausea (19.77%), drowsiness (20.93%); Group 2 vomiting (13.95%), nausea (25.58%), drowsiness (43.02%); and Group 3 vomiting (8.14%), and nausea (13.95%). Conclusion: The dose of 100 mg tramadol/40 mg ketorolac every 8 hours during the first 24 postoperative hours is safe and effective for pain control after open cholecystectomy.

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