1999, Number 3
<< Back Next >>
Alerg Asma Inmunol Pediatr 1999; 8 (3)
Adverse reaction with use of nasal and oral sprays in pediatrics
Carlos M Arroyave Hernández, Rodríguez GMGS
Language: Spanish
References: 23
Page: 90-93
PDF size: 245.34 Kb.
ABSTRACT
In the present paper, we present the adverse reaction observed in 337 children treated with either cromoglycate (oral spray) or beclomethasone dipropionate (nasal spray). The age range was from three weeks old to 12 years. The minimun time of treatment was nine months. The adverse reactions observed were: with cromoglycate (2%) bad taste and with beclomethasone (6%) nasal irritation and dryness. Since the percentage of adverse reactions is very small, both are safe during the treatment of children from three weeks to 12 years of age.
REFERENCES
Konig P. La función del cromoglicato de sodio en el tratamiento del asma. Practical Cardiolog 1987; 13: 1-7.
Cockoft DW, Murdock KY. Comparative effects of inhalated salbutamol, sodium cromoglycate and beclomethasone dipropionate on allergen-induce early asthamic responses, late asthmatic responses and increased bronchial responsivennes to histamine. J Allergy Clin Inunnol 1957; 79: 734-740.
Benoist MR, Brouard JJ, Rufin P, Waenessyckles S et al. Dissociation of symptoms scores and bronchial hyperreactivity: Study in asthmatic children on long term treatment wiht inhaled beclomethasone dipropionate. Pediatr Pulmonol 1992; 13: 71-77.
Dompeling E, Van Grunsven PM, Van Schayck CP, Folgering H et al. Treatment with inhalated steroids in asthma and chronic bronchitis: Long-term compliance and inhale technique. Farm Pract 1992; 9: 161-166.
Rozych HJ, Bryon PR, Dailey K, Gutcher GR. Evaluation of a system for the delivery of inhaled beclomethasone dipropionate to intubated neonates. Dev Pharmacol Ther 1991; 16: 65-70.
Itoh H, Smaldone G, Swift D, Wagner H. Mechanisms of aerosol deposition in a nasal model. J Aerosol Sci 1985; 16: 65-70.
Settipane GA, Klein DE, Boyd GK, Sturam JH et al. Adverse reactions to cromolyn. JAMA 1986; 241: 811-813.
Morrison-Smith J, Pizarro Y. Observations on the safety of disodium cromoglycate in long term use in children. Clin Allergy 1972; 2: 143-151.
Arroyave CM. Reacciones adversas con el cromoglicato de sodio en forma de aerosol bucal en niños menores de 3 años de edad. Arch Ped Mex 1998; 1.
Morrow BH, Jackson FA. Are steroids inhalers safer than tablets? Lancet 1979; 1: 827.
Morrow BH, Storey G, Geargo WHS. Beclomethasone dipropionate: A new steroid aerosol for the treatment of allergic asthma. Br Med J 1972; 1: 585-590.
Winder J, Bell T, Brodsky L et al. A comparative study of intranasal triamcinolone acetonide aerosol and intranasal beclomethasone dipropionate aquoeus spray in perennial allergic rhinitis. Immuno Allergy Prac 1993; 15: 203-209.
Corr D, Dolovich M, McCormack D, Ruffin R et al. Design and characteristics of a portable breathactivated particle size selective medical aerosol inhaler. J Aerosol Sci 1982; 13: 1-7.
Henry RL, Milner AD, Davies JG. Simple drug delivery systems for use by young asthmatics. Br Med J 1983; 286: 2021-2024.
Lee H, Evans H. Aerosol bag for administration of bronchodilators to young asthmatics children. Pediatrics 1984; 73: 230-232.
Conner WT, Dolovich MB, Frame RA, Newhouse MT. Reliable salbutamol administration in 6-to 36 month-old children by means of a metered dose inhaler and aerochamber with mask. Pediatr Pulmonol 1989; 6: 263-2670
Chambers WB, Malfitan VA. Beclomethasones dipropionate aerosol in the treatment of asthma in steroid-independet children. J Internal Med Research 1979; 7: 415-422.
Li Y. Influence of beclomethasone dipropionate on rabbit’s nasal mucosa, adrenal an frog oral mucociliary activities. Chung Hua Erh Yen Hou Ko Tsa Chih 1991; 26: 135-137.
Bhan GL, Gwynn CM, Morrison SJ. Growth and adrenal function of children on prolonged beclomethasone dipropionate treatment. Lancet 1980; 1: 96-97.
Godfriy S, Koning O. Treatment of childhood asthma for 13 months and longer with beclomethasone dipropionate aerosol. Arch Dis Child 1974; 49: 591-596.
Phillip M, Aviram M, Liebernam E, Zadik Z, Giat Y et al. Integrated plasma cortisol concentration in children with asthma receiving long-term inhaled corticosteroids. Pediatr Pulmonol 1992; 12: 84-89.
Katsunuma T, Akasawa A, Iikura Y. Adrenal function of children with bronchial asthma treated with beclomethasone dipropionate. Ann Allergy 1992; 69: 529-532.
Aylet SE, Atherton DJ, Preece MA. The treatment of difficult atopic dermatitis in childhood with oral beclomethasone dipropionate. Acta Derm Venereol (Stock) 1992; 71: 127-135.