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Coordinación General de Investigación de la Facultad de Salud Pública y Nutrición y la Dirección General de Sistemas e Informática de la Universidad Autónoma de Nuevo León

2003, Number 3

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Rev Salud Publica Nutr 2003; 4 (3)

Genética de la diabetes mellitus tipo 2 en el noreste de México. III. Alta prevalencia en los individuos con los apellidos Martínez y Rodríguez

Cerda-Flores RM, Dávila-Rodríguez MI, Cortés-Gutiérrez EI, Rivera-Prieto RA, Calderón-Garcidueñas AL, Gaspar-Belmonte JA, Ibarra-Costilla E, Rojas-Alvarado MA

Language: Spanish
References: 28
Page:
PDF size: 104.70 Kb.


ABSTRACT

Hereditary disorders are classified in three big groups: chromosomic, simple mendelian and multifactorial. Type 2 diabetes mellitus (DM2) is a multifactorial disease. Two previous researches of this multicentric project shows: I. Mexican people whose 4 grandparents immigrated to Nuevo León (NL) have a bigger prevalence of DM2 by sex and age (17.7%) than those whose 4 grandparents were born in NL (13.7%). II. Mexican people with a polyphyletic last name from the two they have (Martínez, García, Rodríguez, Sánchez), show an extra motive 6 times bigger to develop DM2 than mexican people with a monophyletic last name (Garza, Chapa, Treviño, Montemayor, and Cantú). 1)Compare the genetic structure of individuals with both last names: Monophyletic-Monophyletic (MM), Monophyletic-Polyphyletic (MP), and Polyphyletic-Polyphyletic(PP), and 2) know what are the last names of PP individuals with a bigger prevalence of DM2. About 207 people were selected from a previous DM2 research (transversal and comparative) in 2077 mexican people who looked for medical attention in 8 clinics of IMSS from 2001 to 2002. These people were asked about the place where their 4 grandparents were born, sex, age and if they had diabetes, the age they were when it started. These individuals were diagnosed with diabetes by a medical examination based on the glucose levels of the OMS. People were grouped in 60 MM individuals, 84 MP individuals, and 63 PP individuals. ABO and Rh phenotypes were used to estimate ancestral contributions: Spanish (E), Indian (I), and African (A) for each group. Genetic structure of Mexican MM group (E=93%, I=6% and A=1%) was similar to Mexican PP group (E=92%, I=7%, and A=1%). In the Mexican PP group those with one or both last names Martínez or Rodríguez had a bigger prevalence of DM2 (81.3%) and an OR three times bigger than those who don’t have these last names (18.5%). The fact to find in the PP group that individuals with Martínez and Rodríguez last names have a high susceptibility to DM2 will allow us to seek in an easy way genes involved in this metabolic disorder through the use of high density maps (MAD) of SNPs ("Single Nucleotide Polymorphisms").


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