Flores-Nava G, Barrera-Vázquez CN, Fuente-Torres MA, Torres-Narváez P

Language: Spanish
References: 21
Page: 425-430
PDF size: 116.65 Kb.

ABSTRACT

Introduction. Retinopathy of prematurity (ROP) is an alteration in the development of the vessels of the retina with an incidence ranging from 12 to 78%. We undertook this study to determine risk factors associated with ROP in a group of premature infants.
Methods. This is a retrospective and comparative study in search of risk factors of ROP, reviewing the records of infants weighing ‹ 1500 g or gestational age ≤ 30 weeks admitted to the Neonatology Department. We carried out an ophthalmoscopy study at 4 weeks of age and then weekly until hospital discharge. We compared the group with and without retinopathy. Variables registered were birth weight, gestational age, oxygen exposure, total parenteral nutrition, antibiotics, lung disease, severe perinatal asphyxia, peri-intraventricular hemorrhage, septicemia, hyperbilirubinemia, bronchopulmonary dysplasia and red blood cell transfusion. Comparative analysis was carried out by ANOVA and logistic regression by calculating odds ratios (OR) and 95% confidence interval (95% CI).
Results. We reviewed 112 infants with ROP and 95 infants without ROP. According to gender ratio, birth weight, gestational age, mechanical ventilation and days with ventilation, there was no significant difference. Risk factors were antibiotics (OR 2.36, 95% CI 1.22-4.59)), erythrocyte transfusion (OR 2.99, 95% CI 1.50-5.99), total parenteral nutrition (OR 3.20, 95% CI 1.63-6.25), and sepsis (OR 1.83, 95% CI 1.01-3.34).
Conclusions. ROP was present mainly in infants with very serious disease and risk factors were antibiotics, erythrocyte transfusion, total parenteral nutrition and sepsis.

REFERENCES

1. Grunauer N, Iriondo SM. Retinopatía del prematuro. Casuística de los años 1995-2001. An Pediatr. 2003; 58: 471-7.

2. Hussain N, Clive J, Bhandari V. Current incidence of retinopathy of prematurity, 1989-1997. Pediatrics. 1999; 104: e26-32.

3. Pallás ACR, Tejadas PP. Retinopatía del prematuro: nuestra experiencia. An Esp Pediatr. 1995; 42: 52-6.

4. Blair BM, O’Halloran HS, Pauly TH, Stevens JL. Decreased incidence of retinopathy of prematurity 1995-1997. J AAPOS. 2001; 5: 118-22.

5. Fledelius HC, Kjer B. Surveillance for retinopathy of prematurity in a Danish country. Epidemiological experience over 20 years. Acta Ophthalmol Scand. 2004; 82: 38-41.

6. Lavalle VA, Flores NG, Solares PM, Pérez BMM, de la Fuente TMA. Factores de riesgo asociados a retinopatía del prematuro. Rev Mex Pediatr. 2005; 72: 221-5.

7. Sepúlveda CF, Flores SR, Hernández CMA, Hernández HR, Hinojosa PJO, Medinilla VMG. Detección y tratamiento oportuno de la retinopatía de la prematurez. Arch Invest Pediatr Mex. 2003; 6: 5-11.

8. Orozco GLP, Ruiz MI, Lambarry AA, Morales CMV. Prevalencia de retinopatía del prematuro: 12 años de detección en el Centro Médico 20 de Noviembre. Cir Cir. 2006; 74: 3-9.

9. Flores SR, Hernández CMA, Hernández HRJ, Sepúlveda CF. Screening for retinopathy of prematurity: Results of a 7-year study. Arch Med Res. 2007; 38: 440-3.

10. Gaugler C, Beladdale J, Astruc D, Schaffer D, Donato L, Speeg-Schatz C, et al. Retinopathy of prematurity: 10-year retrospective study at the University Hospital of Strasburg. Arch Pediatr. 2002; 9: 350-7.

11. Palmer EA, Hardy RJ, Dobson V, Phelps DL, Quinn GE, Summers CG. 15 year outcomes following threshold retinopathy of prematurity final results from the multicenter trial of retinopathy of prematurity. Arch Ophthalmol. 2005; 123: 311-8.

12. Allegaert K, de Coen K, Devliger H. Threshold retinopathy at threshold of viability: The EpiBel study. Br J Ophthalmol. 2004; 88: 239-42.

13. American Academy of Pediatrics. American Academic of Ophthalmologists. American Association of Ophthalmologists and Strabismus. Screening examination of premature infants for retinopathy of prematurity. Pediatrics. 2001; 108: 809-11.

14. The Committee for the Classification of Retinopathy of Prematurity. An International Classification of retinopathy of prematurity. Pediatrics. 1984; 74: 127-33.

15. Olea VJL, Corretger RFJ. Factores de riesgo en la retinopatía de la prematuridad. An Esp Pediatr. 1997; 47: 172-6.

16. De la Fuente TMA, Ortíz GEV, Bustos ZM, Brechtell BM. Retinopatía del prematuro. Rev Hosp Gral Dr. M Gea González. 2001; 4: 133-7.

17. Brooks SE, Marcus DM, Gillis D, Pirie E, Johnson MH, Bhatia J. The effect of blood transfusion protocol on retinopathy of prematurity: A prospective, randomized study. Pediatrics. 1999; 104: 514-8.

18. Cooke RW, Clarke D, Hickey-Dwyer M, Weindling AM. The apparent role of blood transfusions in the development of retinopathy of prematurity. Eur J Pediatr. 1993; 152: 833-6.

19. Hubbler A, Knote K, Kauf E, Barz D, Schlenvoigt D, Schramm D. Does insulin-like growth factor 1 contribute in red blood cell transfusion to the pathogenesis of retinopathy of prematurity during retinal neovascularization? Biol Neonate. 2006; 89: 92-8.

20. Ikeda H, Kuriyama S. Risk factors for retinopathy of prematurity requiring photocoagulation. Jpn J Ophthalmol. 2004; 48: 68-71.

21. Termote JUM, Donders ART, Schalij-Delfos NE, Lenselink CH, Derken van Angeren CS, Lissone SCJL, et al. Can screening for retinopathy of prematurity be reduced? Biol Neonate. 2005; 88: 92-7.