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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2008, Number 3

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Rev Biomed 2008; 19 (3)

Mechanisms of transmission of human Herpesvirus 8: a current challenge

Martínez-Rodríguez PA, Kourí-Cardellá V

Language: Spanish
References: 53
Page: 170-178
PDF size: 0. Kb.


ABSTRACT

At present, human herpesvirus or Kaposi Sarcoma-Herpes virus associated (KSHV) has been associated with the four clinical forms of Kaposi Sarcoma (classic, endemic, iatrogenic end epidemic), the primary effusion lymphoma and multicentric Castleman disease (MCD). In this review, we discuss the main hypotheses about transmission patterns of this oncogenic virus, since the pathogenic mechanisms of infection and the human to human transmission have not been fully elucidated as yet. Although Kaposi Sarcoma is not a frequent disease in Cuba, the results of studies performed by Cuban authors have demonstrated the presence of this agent in our country and its association with the variants of the epidemic and classic Kaposi Sarcoma in Cuban individuals.
The knowledge of possible mechanisms involved in KSHV spread from one person to another will determine possible actions for reduction of infection by KSHV, particulary in higher risk groups.


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