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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2008, Número 3

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Rev Biomed 2008; 19 (3)


Mecanismos de transmisión del Herpesvirus humano 8: un reto actual

Martínez-Rodríguez PA, Kourí-Cardellá V

Idioma: Español
Referencias bibliográficas: 53
Paginas: 170-178
Archivo PDF: 0. Kb.


RESUMEN

Actualmente se reconoce la participación del Herpesvirus Humano 8 (Hvh-8) o Herpesvirus Asociado al Sarcoma de Kaposi (HASK) en las cuatro variantes clínicas del Sarcoma de Kaposi (SK) (clásico, endémico, iatrogénico y epidémico), en el Linfoma de Efusión Primaria (LEP) y en la Enfermedad Multicéntrica de Castleman (EMC).
En la presente revisión se presentan y discuten las principales hipótesis sobre la transmisión de este virus oncogénico, ya que actualmente no se han podido esclarecer categóricamente los mecanismos de la patogenia de su infección ni las vías de transmisión humano-humano. Aunque el SK no es una enfermedad frecuente en Cuba, los resultados de estudios realizados por autores cubanos han demostrado la presencia de este agente en nuestro país y su asociación con las variantes del SK epidémico y clásico en individuos cubanos.
El conocimiento de los posibles mecanismos involucrados en el paso de un individuo a otro definirá las posibles acciones para la reducción de la infección por el HASK, especialmente en grupos de mayor riesgo.


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